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dc.contributor.authorRobinson, Philipen
dc.contributor.authorCollins, Conor Den
dc.contributor.authorRyder, W David Jen
dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorHutchinson, Charles Een
dc.contributor.authorBell, Den
dc.contributor.authorLogue, John Pen
dc.contributor.authorRead, Gen
dc.contributor.authorCowan, Richard Aen
dc.date.accessioned2009-11-23T10:16:58Z
dc.date.available2009-11-23T10:16:58Z
dc.date.issued2000-04
dc.identifier.citationRelationship of MRI and clinical staging to outcome in invasive bladder cancer treated by radiotherapy. 2000, 55 (4):301-6 Clin Radiolen
dc.identifier.issn0009-9260
dc.identifier.pmid10767191
dc.identifier.doi10.1053/crad.1999.0381
dc.identifier.urihttp://hdl.handle.net/10541/86648
dc.description.abstractAIM: To compare MRI and clinical staging of invasive bladder cancer prospectively and identify additional prognostic features on MRI before radiotherapy. METHODS AND MATERIALS: 143 patients with a pathological diagnosis of transitional cell carcinoma underwent MRI (1.0 T) of the abdomen and pelvis before radical radiotherapy. Tumour size, site, degree of infiltration, presence of adenopathy and hydronephrosis were assessed and an appropriate radiological stage assigned. Following radiotherapy all patients received regular cystoscopic follow-up. Date of first relapse and date of death were recorded. RESULTS: The median follow-up was 2.8 years for survivors. Those patients upstaged from T2a clinically to T3b on MRI had a significantly worse outcome (P = 0.0078). In univariate analysis a number of MRI features were significantly associated with adverse outcome: tumour size, circumferential tumour extent, and presence of hydronephrosis (all P < 0.05). After adjustment for clinical T stage and histological grade, all these MRI features and the MRI T stage were found to confer additional prognostic information in predicting early disease relapse and death (P < 0.05). CONCLUSION: This study demonstrates that MRI before radiotherapy provides valuable additional prognostic information compared to clinical staging.
dc.language.isoenen
dc.subjectCancer Invasivenessen
dc.subjectCancer Stagingen
dc.subjectUrinary Bladder Canceren
dc.subject.meshAged
dc.subject.meshAnalysis of Variance
dc.subject.meshCarcinoma, Transitional Cell
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Invasiveness
dc.subject.meshNeoplasm Staging
dc.subject.meshPrognosis
dc.subject.meshProspective Studies
dc.subject.meshSurvival Rate
dc.subject.meshTreatment Outcome
dc.subject.meshUrinary Bladder Neoplasms
dc.titleRelationship of MRI and clinical staging to outcome in invasive bladder cancer treated by radiotherapy.en
dc.typeArticleen
dc.contributor.departmentDepartments of Diagnostic Radiology, Christie Hospital, Manchester, UK.en
dc.identifier.journalClinical Radiologyen
html.description.abstractAIM: To compare MRI and clinical staging of invasive bladder cancer prospectively and identify additional prognostic features on MRI before radiotherapy. METHODS AND MATERIALS: 143 patients with a pathological diagnosis of transitional cell carcinoma underwent MRI (1.0 T) of the abdomen and pelvis before radical radiotherapy. Tumour size, site, degree of infiltration, presence of adenopathy and hydronephrosis were assessed and an appropriate radiological stage assigned. Following radiotherapy all patients received regular cystoscopic follow-up. Date of first relapse and date of death were recorded. RESULTS: The median follow-up was 2.8 years for survivors. Those patients upstaged from T2a clinically to T3b on MRI had a significantly worse outcome (P = 0.0078). In univariate analysis a number of MRI features were significantly associated with adverse outcome: tumour size, circumferential tumour extent, and presence of hydronephrosis (all P < 0.05). After adjustment for clinical T stage and histological grade, all these MRI features and the MRI T stage were found to confer additional prognostic information in predicting early disease relapse and death (P < 0.05). CONCLUSION: This study demonstrates that MRI before radiotherapy provides valuable additional prognostic information compared to clinical staging.


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