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    Relationship of MRI and clinical staging to outcome in invasive bladder cancer treated by radiotherapy.

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    Authors
    Robinson, Philip
    Collins, Conor D
    Ryder, W David J
    Carrington, Bernadette M
    Hutchinson, Charles E
    Bell, D
    Logue, John P
    Read, G
    Cowan, Richard A
    Affiliation
    Departments of Diagnostic Radiology, Christie Hospital, Manchester, UK.
    Issue Date
    2000-04
    
    Metadata
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    Abstract
    AIM: To compare MRI and clinical staging of invasive bladder cancer prospectively and identify additional prognostic features on MRI before radiotherapy. METHODS AND MATERIALS: 143 patients with a pathological diagnosis of transitional cell carcinoma underwent MRI (1.0 T) of the abdomen and pelvis before radical radiotherapy. Tumour size, site, degree of infiltration, presence of adenopathy and hydronephrosis were assessed and an appropriate radiological stage assigned. Following radiotherapy all patients received regular cystoscopic follow-up. Date of first relapse and date of death were recorded. RESULTS: The median follow-up was 2.8 years for survivors. Those patients upstaged from T2a clinically to T3b on MRI had a significantly worse outcome (P = 0.0078). In univariate analysis a number of MRI features were significantly associated with adverse outcome: tumour size, circumferential tumour extent, and presence of hydronephrosis (all P < 0.05). After adjustment for clinical T stage and histological grade, all these MRI features and the MRI T stage were found to confer additional prognostic information in predicting early disease relapse and death (P < 0.05). CONCLUSION: This study demonstrates that MRI before radiotherapy provides valuable additional prognostic information compared to clinical staging.
    Citation
    Relationship of MRI and clinical staging to outcome in invasive bladder cancer treated by radiotherapy. 2000, 55 (4):301-6 Clin Radiol
    Journal
    Clinical Radiology
    URI
    http://hdl.handle.net/10541/86648
    DOI
    10.1053/crad.1999.0381
    PubMed ID
    10767191
    Type
    Article
    Language
    en
    ISSN
    0009-9260
    ae974a485f413a2113503eed53cd6c53
    10.1053/crad.1999.0381
    Scopus Count
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    All Christie Publications

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