Relationship of MRI and clinical staging to outcome in invasive bladder cancer treated by radiotherapy.
Collins, Conor D
Ryder, W David J
Carrington, Bernadette M
Hutchinson, Charles E
Logue, John P
Cowan, Richard A
AffiliationDepartments of Diagnostic Radiology, Christie Hospital, Manchester, UK.
MetadataShow full item record
AbstractAIM: To compare MRI and clinical staging of invasive bladder cancer prospectively and identify additional prognostic features on MRI before radiotherapy. METHODS AND MATERIALS: 143 patients with a pathological diagnosis of transitional cell carcinoma underwent MRI (1.0 T) of the abdomen and pelvis before radical radiotherapy. Tumour size, site, degree of infiltration, presence of adenopathy and hydronephrosis were assessed and an appropriate radiological stage assigned. Following radiotherapy all patients received regular cystoscopic follow-up. Date of first relapse and date of death were recorded. RESULTS: The median follow-up was 2.8 years for survivors. Those patients upstaged from T2a clinically to T3b on MRI had a significantly worse outcome (P = 0.0078). In univariate analysis a number of MRI features were significantly associated with adverse outcome: tumour size, circumferential tumour extent, and presence of hydronephrosis (all P < 0.05). After adjustment for clinical T stage and histological grade, all these MRI features and the MRI T stage were found to confer additional prognostic information in predicting early disease relapse and death (P < 0.05). CONCLUSION: This study demonstrates that MRI before radiotherapy provides valuable additional prognostic information compared to clinical staging.
CitationRelationship of MRI and clinical staging to outcome in invasive bladder cancer treated by radiotherapy. 2000, 55 (4):301-6 Clin Radiol
- Treatment outcome and prognostic variables for local control and survival in patients receiving radical radiotherapy for urinary bladder cancer.
- Authors: Fokdal L, Høyer M, von der Maase H
- Issue date: 2004
- [Long-term survival of bladder preservation therapy with radiation and chemotherapy for locally invasive bladder cancer].
- Authors: Noguchi S, Takase K, Kubota Y, Masuda M, Yao M, Hosaka M
- Issue date: 1998 Mar
- Results of the phase II EORTC 22971 trial evaluating combined accelerated external radiation and chemotherapy with 5FU and cisplatin in patients with muscle invasive transitional cell carcinoma of the bladder.
- Authors: Poortmans PM, Richaud P, Collette L, Ho Goey S, Pierart M, Van Der Hulst M, Bolla M, EORTC Radiation Oncology Group.
- Issue date: 2008
- Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy.
- Authors: George L, Bladou F, Bardou VJ, Gravis G, Tallet A, Alzieu C, Serment G, Salem N
- Issue date: 2004 Sep