Relationship of MRI and clinical staging to outcome in invasive bladder cancer treated by radiotherapy.
Authors
Robinson, PhilipCollins, Conor D
Ryder, W David J
Carrington, Bernadette M
Hutchinson, Charles E
Bell, D
Logue, John P
Read, G
Cowan, Richard A
Affiliation
Departments of Diagnostic Radiology, Christie Hospital, Manchester, UK.Issue Date
2000-04
Metadata
Show full item recordAbstract
AIM: To compare MRI and clinical staging of invasive bladder cancer prospectively and identify additional prognostic features on MRI before radiotherapy. METHODS AND MATERIALS: 143 patients with a pathological diagnosis of transitional cell carcinoma underwent MRI (1.0 T) of the abdomen and pelvis before radical radiotherapy. Tumour size, site, degree of infiltration, presence of adenopathy and hydronephrosis were assessed and an appropriate radiological stage assigned. Following radiotherapy all patients received regular cystoscopic follow-up. Date of first relapse and date of death were recorded. RESULTS: The median follow-up was 2.8 years for survivors. Those patients upstaged from T2a clinically to T3b on MRI had a significantly worse outcome (P = 0.0078). In univariate analysis a number of MRI features were significantly associated with adverse outcome: tumour size, circumferential tumour extent, and presence of hydronephrosis (all P < 0.05). After adjustment for clinical T stage and histological grade, all these MRI features and the MRI T stage were found to confer additional prognostic information in predicting early disease relapse and death (P < 0.05). CONCLUSION: This study demonstrates that MRI before radiotherapy provides valuable additional prognostic information compared to clinical staging.Citation
Relationship of MRI and clinical staging to outcome in invasive bladder cancer treated by radiotherapy. 2000, 55 (4):301-6 Clin RadiolJournal
Clinical RadiologyDOI
10.1053/crad.1999.0381PubMed ID
10767191Type
ArticleLanguage
enISSN
0009-9260ae974a485f413a2113503eed53cd6c53
10.1053/crad.1999.0381
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