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dc.contributor.authorSteven, F S
dc.contributor.authorEl-Teraifi, H
dc.contributor.authorDenton, J
dc.contributor.authorMarkidou, S G
dc.contributor.authorDelinassios, J G
dc.date.accessioned2009-11-23T10:13:46Z
dc.date.available2009-11-23T10:13:46Z
dc.date.issued2000
dc.identifier.citationFluorescent location of malignant cells in fine needle aspirates., 20 (6C):4871-6 Anticancer Res.en
dc.identifier.issn0250-7005
dc.identifier.pmid11205235
dc.identifier.urihttp://hdl.handle.net/10541/86647
dc.description.abstractMalignant cells in fine needle aspirates possess a cell surface protease which can be targeted with fluorescent affinity probes. Cells with active GB exhibit cell surface fluorescence when stained with such affinity probes. The nuclei of all cells on the slides can be counterstained with a nuclear fluorescent stain. Malignant cells are then located by their cell surface fluorescence and their diagnosis confirmed by examining their fluorescent nuclei. Normal cells and benign cells exhibit no cell surface fluorescence and can be ignored. This technique can be used to rapidly select cells of cytological interest in FNA samples obtained routinely and might be adapted for automated screening of FNA.
dc.language.isoenen
dc.subjectCanceren
dc.subjectCancer Pathologyen
dc.subject.meshAutomation
dc.subject.meshBiopsy, Needle
dc.subject.meshCell Membrane
dc.subject.meshEndopeptidases
dc.subject.meshHumans
dc.subject.meshMicroscopy, Fluorescence
dc.subject.meshNeoplasms
dc.titleFluorescent location of malignant cells in fine needle aspirates.en
dc.typeArticleen
dc.contributor.departmentDivision of Biochemistry, School of Biological Sciences, University of Manchester, Manchester M13 9PT, U.K.en
dc.identifier.journalAnticancer Researchen
html.description.abstractMalignant cells in fine needle aspirates possess a cell surface protease which can be targeted with fluorescent affinity probes. Cells with active GB exhibit cell surface fluorescence when stained with such affinity probes. The nuclei of all cells on the slides can be counterstained with a nuclear fluorescent stain. Malignant cells are then located by their cell surface fluorescence and their diagnosis confirmed by examining their fluorescent nuclei. Normal cells and benign cells exhibit no cell surface fluorescence and can be ignored. This technique can be used to rapidly select cells of cytological interest in FNA samples obtained routinely and might be adapted for automated screening of FNA.


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