Fluorescent location of malignant cells in fine needle aspirates.
Affiliation
Division of Biochemistry, School of Biological Sciences, University of Manchester, Manchester M13 9PT, U.K.Issue Date
2000
Metadata
Show full item recordAbstract
Malignant cells in fine needle aspirates possess a cell surface protease which can be targeted with fluorescent affinity probes. Cells with active GB exhibit cell surface fluorescence when stained with such affinity probes. The nuclei of all cells on the slides can be counterstained with a nuclear fluorescent stain. Malignant cells are then located by their cell surface fluorescence and their diagnosis confirmed by examining their fluorescent nuclei. Normal cells and benign cells exhibit no cell surface fluorescence and can be ignored. This technique can be used to rapidly select cells of cytological interest in FNA samples obtained routinely and might be adapted for automated screening of FNA.Citation
Fluorescent location of malignant cells in fine needle aspirates., 20 (6C):4871-6 Anticancer Res.Journal
Anticancer ResearchPubMed ID
11205235Type
ArticleLanguage
enISSN
0250-7005Collections
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