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    Fluorescent location of malignant cells in fine needle aspirates.

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    Authors
    Steven, F S
    El-Teraifi, H
    Denton, J
    Markidou, S G
    Delinassios, J G
    Affiliation
    Division of Biochemistry, School of Biological Sciences, University of Manchester, Manchester M13 9PT, U.K.
    Issue Date
    2000
    
    Metadata
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    Abstract
    Malignant cells in fine needle aspirates possess a cell surface protease which can be targeted with fluorescent affinity probes. Cells with active GB exhibit cell surface fluorescence when stained with such affinity probes. The nuclei of all cells on the slides can be counterstained with a nuclear fluorescent stain. Malignant cells are then located by their cell surface fluorescence and their diagnosis confirmed by examining their fluorescent nuclei. Normal cells and benign cells exhibit no cell surface fluorescence and can be ignored. This technique can be used to rapidly select cells of cytological interest in FNA samples obtained routinely and might be adapted for automated screening of FNA.
    Citation
    Fluorescent location of malignant cells in fine needle aspirates., 20 (6C):4871-6 Anticancer Res.
    Journal
    Anticancer Research
    URI
    http://hdl.handle.net/10541/86647
    PubMed ID
    11205235
    Type
    Article
    Language
    en
    ISSN
    0250-7005
    Collections
    All Christie Publications

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