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    Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?

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    Authors
    Ng, Antony
    Taylor, G Malcolm
    Eden, Tim O B
    Affiliation
    Academic Department of Paediatric Oncology, Christie Hospital, Manchester, UK.
    Issue Date
    2000
    
    Metadata
    Show full item record
    Abstract
    To date little has been reported about the risk of therapy-related leukaemia (t-AML) in children receiving oral etoposide therapy. The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose. The leukemic blasts were examined by morphological, immunohistochemical, cytogenetic, and molecular genetic analyses. Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated. The use of modern multiagent therapy often makes it difficult to appropriately apportion blame for causation of specific side effects. Moreover, the etiology of t-AML and mechanism of leukemogenesis are likely to be multifactorial and complex. Further studies on the precise association with different therapies are thus needed. Oral etoposide remains an effective palliative agent and its usage should not be excluded without most careful consideration of the risks.
    Citation
    Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?, 17 (3):273-9 Pediatr Hematol Oncol
    Journal
    Pediatric Hematology and Oncology
    URI
    http://hdl.handle.net/10541/86536
    DOI
    10.1080/088800100276460
    PubMed ID
    10779995
    Type
    Article
    Language
    en
    ISSN
    0888-0018
    ae974a485f413a2113503eed53cd6c53
    10.1080/088800100276460
    Scopus Count
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    All Christie Publications

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