Successful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia.
Affiliation
Department of Pathology, Royal Manchester Children's Hospital, UK.Issue Date
2000-09
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Cerebral aspergillosis carries a high mortality in immunocompromised patients. However, favorable outcome can be achieved by the prolonged use of antifungal agents and the maintenance of adequate drug levels. The authors report a 2-year-old girl who developed an aspergillus brain abscess during treatment for acute lymphoblastic leukemia. Predisposing factors for the fungal infection and details of the antifungal therapy are described. Prolonged treatment with AmBisome and 5-flucytosine successfully eradicated the lesion, but the girl's antileukemic therapy was compromised due to the infection. She developed a central nervous system and bone marrow relapse 9 and 15 months, respectively, after the initial presentation. The report emphasizes the need for further consideration of effective, long-term antifungal prophylaxis and a careful balance between aggressive treatment for severe infection and antileukemic therapy.Citation
Successful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia. 2000, 17 (6):497-504 Pediatr Hematol OncolJournal
Pediatric Hematology and OncologyDOI
10.1080/08880010050120863PubMed ID
10989471Type
ArticleLanguage
enISSN
0888-0018ae974a485f413a2113503eed53cd6c53
10.1080/08880010050120863
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