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    Successful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia.

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    Authors
    Ng, Antony
    Gadong, N
    Kelsey, Anna M
    Denning, David W
    Leggate, J
    Eden, Tim O B
    Affiliation
    Department of Pathology, Royal Manchester Children's Hospital, UK.
    Issue Date
    2000-09
    
    Metadata
    Show full item record
    Abstract
    Cerebral aspergillosis carries a high mortality in immunocompromised patients. However, favorable outcome can be achieved by the prolonged use of antifungal agents and the maintenance of adequate drug levels. The authors report a 2-year-old girl who developed an aspergillus brain abscess during treatment for acute lymphoblastic leukemia. Predisposing factors for the fungal infection and details of the antifungal therapy are described. Prolonged treatment with AmBisome and 5-flucytosine successfully eradicated the lesion, but the girl's antileukemic therapy was compromised due to the infection. She developed a central nervous system and bone marrow relapse 9 and 15 months, respectively, after the initial presentation. The report emphasizes the need for further consideration of effective, long-term antifungal prophylaxis and a careful balance between aggressive treatment for severe infection and antileukemic therapy.
    Citation
    Successful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia. 2000, 17 (6):497-504 Pediatr Hematol Oncol
    Journal
    Pediatric Hematology and Oncology
    URI
    http://hdl.handle.net/10541/86534
    DOI
    10.1080/08880010050120863
    PubMed ID
    10989471
    Type
    Article
    Language
    en
    ISSN
    0888-0018
    ae974a485f413a2113503eed53cd6c53
    10.1080/08880010050120863
    Scopus Count
    Collections
    All Christie Publications

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