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    Treatment-related leukaemia--a clinical and scientific challenge.

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    Authors
    Ng, Antony
    Taylor, G Malcolm
    Eden, Tim O B
    Affiliation
    Immunogenetics Laboratory, St Mary's Hospital, Hathersage Road, Manchester M13 OJH, UK.
    Issue Date
    2000-10
    
    Metadata
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    Abstract
    The development of a second tumour, including treatment-related leukaemia (TRL), is the most devastating complication of intensive cancer chemotherapy. This is especially relevant in the paediatric population as over 70% of children diagnosed with a malignancy will now live at least 5 years. Most TRLs are myeloid leukaemias and carry an overall poor prognosis when compared with their de novo counterparts. Despite the well known association with specific cytotoxic agents, improved understanding of the pathogenesis and risk factors of TRL is ultimately essential if we are to develop successful strategies for prevention and treatment. Here we review these aspects, together with the clinical and diverse biological features of this complication and the efficacy of current therapy.
    Citation
    Treatment-related leukaemia--a clinical and scientific challenge. 2000, 26 (5):377-91 Cancer Treat. Rev.
    Journal
    Cancer Treatment Reviews
    URI
    http://hdl.handle.net/10541/86527
    DOI
    10.1053/ctrv.2000.0186
    PubMed ID
    11006138
    Type
    Article
    Language
    en
    ISSN
    0305-7372
    ae974a485f413a2113503eed53cd6c53
    10.1053/ctrv.2000.0186
    Scopus Count
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