Faslodex (ICI 182780). an oestrogen receptor downregulator.
| dc.contributor.author | Howell, Anthony | |
| dc.date.accessioned | 2009-11-19T15:30:59Z | |
| dc.date.available | 2009-11-19T15:30:59Z | |
| dc.date.issued | 2000-09 | |
| dc.identifier.citation | Faslodex (ICI 182780). an oestrogen receptor downregulator. 2000, 36 Suppl 4:S87-8 Eur. J. Cancer | en |
| dc.identifier.issn | 0959-8049 | |
| dc.identifier.pmid | 11056334 | |
| dc.identifier.doi | 10.1016/S0959-8049(00)00241-0 | |
| dc.identifier.uri | http://hdl.handle.net/10541/86514 | |
| dc.description.abstract | Anti-oestrogen therapy, tamoxifen in particular, has revolutionised the treatment of breast cancer. However, the partial agonist activity of tamoxifen is associated with an increased risk of endometrial cancer and the acquisition by patients of tamoxifen-resistance. In an attempt overcome these negative aspects of tamoxifen therapy, 'pure' anti-oestrogens have been developed and are currently being investigated for the treatment of breast cancer. | |
| dc.language.iso | en | en |
| dc.subject | Breast Cancer | en |
| dc.subject | Oestrogen Receptors | en |
| dc.subject.mesh | Antineoplastic Agents | |
| dc.subject.mesh | Breast Neoplasms | |
| dc.subject.mesh | Clinical Trials, Phase II as Topic | |
| dc.subject.mesh | Down-Regulation | |
| dc.subject.mesh | Estradiol | |
| dc.subject.mesh | Female | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Receptors, Estrogen | |
| dc.title | Faslodex (ICI 182780). an oestrogen receptor downregulator. | en |
| dc.type | Article | en |
| dc.contributor.department | CRC Department of Medical Oncology, Christie Hospital NHS Trust, M20 4BX, Manchester, UK. maria.parker@christie-tr.nwest.nhs.uk | en |
| dc.identifier.journal | European Journal of Cancer | en |
| html.description.abstract | Anti-oestrogen therapy, tamoxifen in particular, has revolutionised the treatment of breast cancer. However, the partial agonist activity of tamoxifen is associated with an increased risk of endometrial cancer and the acquisition by patients of tamoxifen-resistance. In an attempt overcome these negative aspects of tamoxifen therapy, 'pure' anti-oestrogens have been developed and are currently being investigated for the treatment of breast cancer. |