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dc.contributor.authorMcNally, Richard J Q
dc.contributor.authorBirch, Jillian M
dc.contributor.authorTaylor, G Malcolm
dc.contributor.authorEden, Tim O B
dc.date.accessioned2009-11-19T16:43:31Z
dc.date.available2009-11-19T16:43:31Z
dc.date.issued2000-08-05
dc.identifier.citationIncidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England. 2000, 356 (9228):485-6 Lanceten
dc.identifier.issn0140-6736
dc.identifier.pmid10981897
dc.identifier.doi10.1016/S0140-6736(00)02562-9
dc.identifier.urihttp://hdl.handle.net/10541/86510
dc.description.abstractA temporal increase in the incidence of childhood acute lymphoblastic leukaemia (ALL) in the UK has been noted. We present data from the Manchester Children's Tumour Registry which provide strong evidence that the increase is a result of an increase in the precursor B-cell subtype. In the childhood peak (age 1-4 years), the annual increase in precursor B-cell ALL between 1980 and 1998 was 3.0% (p=0.024). Recent findings are consistent with the causal involvement of infections in precursor B-cell ALL.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshEngland
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.titleIncidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England.en
dc.typeArticleen
dc.identifier.journalLanceten
html.description.abstractA temporal increase in the incidence of childhood acute lymphoblastic leukaemia (ALL) in the UK has been noted. We present data from the Manchester Children's Tumour Registry which provide strong evidence that the increase is a result of an increase in the precursor B-cell subtype. In the childhood peak (age 1-4 years), the annual increase in precursor B-cell ALL between 1980 and 1998 was 3.0% (p=0.024). Recent findings are consistent with the causal involvement of infections in precursor B-cell ALL.


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