• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Li, Chenggang
    Guo, Baoqiang
    Wilson, Philip B
    Stewart, Alan L
    Byrne, Ged J
    Bundred, Nigel J
    Kumar, Shant
    Affiliation
    Department of Pathological Sciences, Medical School, University of Manchester, UK.
    Issue Date
    2000-03-20
    
    Metadata
    Show full item record
    Abstract
    CD105 (endoglin), a receptor for transforming growth factor (TGF) beta1 and beta3 in vascular endothelial cells, is highly up-regulated in blood vessels of tissues where neovascularisation occurs. It modulates endothelial-mesenchymal signalling and is essential for angiogenesis. Indeed, CD105 knock-out mice die from malvascularisation by 11.5 day p.c. In the present study CD105, TGFbeta1 and CD105/TGFbeta1 complexes were quantified in plasma samples from 77 healthy individuals and 92 patients with early stage breast cancer prior to any treatment. When compared with normal controls, both CD105 and CD105/TGFbeta1 complex levels were significantly elevated in breast cancer patients, whereas TGFbeta1 levels were lower in cancer patients. The most important finding to emerge was that CD105 levels were significantly increased in patients who developed distant metastasis compared with disease-free patients. While there was no significant difference between CD105 levels in controls compared to disease-free patients, it was significantly higher in patients with metastatic disease. Thus patients who had died following local relapse or distant metastases possessed the highest levels of CD105. Neither CD105/TGFbeta1 complex nor TGFbeta1 levels correlated with tumour progression. Our data indicate that CD105 might be a valuable novel angiogenic marker for identifying breast cancer patients who are at high risk of developing metastasis.
    Citation
    Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer. 2000, 89 (2):122-6 Int. J. Cancer
    Journal
    International Journal of Cancer
    URI
    http://hdl.handle.net/10541/86509
    DOI
    10.1002/(SICI)1097-0215(20000320)89:2<122::AID-IJC4>3.0.CO;2-M
    PubMed ID
    10754488
    Type
    Article
    Language
    en
    ISSN
    0020-7136
    ae974a485f413a2113503eed53cd6c53
    10.1002/(SICI)1097-0215(20000320)89:2<122::AID-IJC4>3.0.CO;2-M
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Role of transforming growth factor beta3 in lymphatic metastasis in breast cancer.
    • Authors: Li C, Wang J, Wilson PB, Kumar P, Levine E, Hunter RD, Kumar S
    • Issue date: 1998 Oct 23
    • Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis.
    • Authors: Li C, Gardy R, Seon BK, Duff SE, Abdalla S, Renehan A, O'Dwyer ST, Haboubi N, Kumar S
    • Issue date: 2003 May 6
    • TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis.
    • Authors: Li C, Wilson PB, Levine E, Barber J, Stewart AL, Kumar S
    • Issue date: 1999 Apr 20
    • Immunodetection and characterisation of soluble CD105-TGFbeta complexes.
    • Authors: Li CG, Wilson PB, Bernabeu C, Raab U, Wang JM, Kumar S
    • Issue date: 1998 Sep 1
    • The significance of CD105, TGFbeta and CD105/TGFbeta complexes in coronary artery disease.
    • Authors: Li CG, Bethell H, Wilson PB, Bhatnagar D, Walker MG, Kumar S
    • Issue date: 2000 Sep
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.