Authors
Lewis, R ARogers, K D
Hall, C J
Towns-Andrews, E
Slawson, S
Evans, A
Pinder, S E
Ellis, I O
Boggis, C R
Hufton, Alan P
Dance, D R
Affiliation
Daresbury Laboratory, Warrington WA4 4AD, UK.Issue Date
2000-09-01
Metadata
Show full item recordAbstract
Small-angle X-ray diffraction data has been collected from 99 ;core-cut' breast tissue specimens representing a number of different pathologies. Data in the range 75-1390 A have been compared with controls from patients with no breast disease. Bessel functions and Bragg maxima resulting from the fibrillar structure of collagen have been identified. The Bragg maxima indexed onto a 649 A lattice. Systematic differences in the intensities and D-spacings between the collagen of malignant, benign and normal tissue groups have been clearly demonstrated and quantified. These differences appear to be due to a significantly lower structural order within the malignant tissues. Possible explanations for this are discussed and the potential for utilizing this observation in cancer diagnosis is considered.Citation
Breast cancer diagnosis using scattered X-rays. 2000, 7 (Pt 5):348-52 J Synchrotron RadiatJournal
Journal of Synchrotron RadiationDOI
10.1107/S0909049500009973PubMed ID
16609219Type
ArticleLanguage
enISSN
0909-0495ae974a485f413a2113503eed53cd6c53
10.1107/S0909049500009973
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