Magnetic resonance imaging screening in women at genetic risk of breast cancer: imaging and analysis protocol for the UK multicentre study. UK MRI Breast Screening Study Advisory Group.
Authors
Brown, JBuckley, D
Coulthard, A
Dixon, A
Dixon, J
Easton, D
Eeles, Rosalind
Evans, D Gareth R
Gilbert, F
Graves, M
Hayes, C
Jenkins, J
Jones, Andrew P
Keevil, S
Leach, M
Liney, G
Moss, S
Padhani, A
Parker, G
Pointon, L
Ponder, B
Redpath, T
Sloane, J
Turnbull, L
Walker, L
Warren, R
Affiliation
Health Economics Research Group, Brunel University, Middlesex, UK.Issue Date
2000-09
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Show full item recordAbstract
The imaging and analysis protocol of the UK multicentre study of magnetic resonance imaging (MRI) as a method of screening for breast cancer in women at genetic risk is described. The study will compare the sensitivity and specificity of contrast-enhanced MRI with two-view x-ray mammography. Approximately 500 women below the age of 50 at high genetic risk of breast cancer will be recruited per year for three years, with annual MRI and x-ray mammography continuing for up to 5 years. A symptomatic cohort will be measured in the first year to ensure consistent reporting between centres. The MRI examination comprises a high-sensitivity three-dimensional contrast-enhanced assessment, followed by a high-specificity contrast-enhanced study in equivocal cases. Multiparametric analysis will encompass morphological assessment, the kinetics of contrast agent uptake and determination of quantitative pharmacokinetic parameters. Retrospective analysis will identify the most specific indicators of malignancy. Sensitivity and specificity, together with diagnostic performance, diagnostic impact and therapeutic impact will be assessed with reference to pathology, follow-up and changes in diagnostic certainty and therapeutic decisions. Mammography, lesion localisation, pathology and cytology will be performed in accordance with the UK NHS Breast Screening Programme quality assurance standards. Similar standards of quality assurance will be applied for MR measurements and evaluation.Citation
Magnetic resonance imaging screening in women at genetic risk of breast cancer: imaging and analysis protocol for the UK multicentre study. UK MRI Breast Screening Study Advisory Group. 2000, 18 (7):765-76 Magn Reson ImagingJournal
Magnetic Resonance ImagingDOI
10.1016/S0730-725X(00)00167-3PubMed ID
11027869Type
ArticleLanguage
enISSN
0730-725Xae974a485f413a2113503eed53cd6c53
10.1016/S0730-725X(00)00167-3
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