AuthorsCooper, Rachel A
Slevin, Nicholas J
Carrington, Bernadette M
Sykes, Andrew J
Birzgalis, Andrew R
Mott, David J
AffiliationDepartment of Clinical Oncology, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.
MetadataShow full item record
AbstractPosterior pharyngeal carcinoma has an extremely poor prognosis regardless of the method of treatment. The purpose of this study was to assess the local control and survival in patients with carcinoma of the posterior pharyngeal wall treated with definitive radiotherapy and to determine prognostic factors which may be relevant to the current UICC staging classification. Between January 1991 and December 1995, 22 patients with a mean age of 60 years (range 44-82) received definitive radiotherapy, using a homogeneous technique, for carcinoma of the posterior pharyngeal wall. The median follow-up was 42 months (range 25-66). The overall 3-year survival and local control for the whole group was 50% and 73% respectively. Patients with early stage (T1 and T2) disease had a significantly better overall 3-year survival rate of 77% compared to 11% for patients with advanced stage (T3 and T4) disease (p=0.0010). Similarly, patients with early stage disease had a significantly improved 3-year local control rate compared to patients with more advanced stage disease (92% and 44% respectively, p=0.0080). Patients with node positive disease had an inferior survival rate of 29% compared to 60% for those with node negative disease though the difference did not reach statistical significance. In addition only one patient with initial node negative disease had isolated nodal relapse. There was no significant late morbidity. For patients with early stage disease we have obtained local control and survival rates comparable to other groups with a once daily, short fractionation radiotherapy scheme but with reduced morbidity. In late stage disease altered fractionation schemes should be considered in order to achieve better local control and survival. Isolated nodal relapse was not a significant problem in this cohort of patients. Outcome correlates with primary tumour size and this is reflected in the current UICC staging classification.
CitationRadiotherapy for carcinoma of the posterior pharyngeal wall. 2000, 16 (3):611-5 Int. J. Oncol.
JournalInternational Journal of Oncology
- Squamous cell carcinoma of the pharyngeal walls treated with radiotherapy.
- Authors: Chang L, Stevens KR, Moss WT, Marquez Cm, Pearse HD, Cohen JI
- Issue date: 1996 Jun 1
- Treatment results and prognostic factors of early breast cancer treated with a breast conserving operation and radiotherapy.
- Authors: Kim KJ, Huh SJ, Yang JH, Park W, Nam SJ, Kim JH, Lee JH, Kang SS, Lee JE, Kang MK, Park YJ, Nam HR
- Issue date: 2005 Mar
- Adjuvant high-dose-rate brachytherapy after external beam radiotherapy in nasopharyngeal carcinoma.
- Authors: Ozyar E, Yildz F, Akyol FH, Atahan IL
- Issue date: 2002 Jan 1
- Dose escalation using twice-daily radiotherapy for nasopharyngeal carcinoma: does heavier dosing result in a happier ending?
- Authors: Jen YM, Lin YS, Su WF, Hsu WL, Hwang JM, Chao HL, Liu DW, Chen CM, Lin HY, Wu CJ, Chang LP, Shueng PW
- Issue date: 2002 Sep 1
- Definitive radiotherapy alone or combined with a planned neck dissection for squamous cell carcinoma of the pharyngeal wall.
- Authors: Hull MC, Morris CG, Tannehill SP, Werning JW, Amdur RJ, Hinerman RW, Villaret DB, Mendenhall WM
- Issue date: 2003 Nov 15