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    MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study.

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    Authors
    Cuthbert, G
    Thompson, K
    McCullough, S
    Watmore, A
    Dickinson, H
    Telford, Nicholas
    Mugneret, F
    Harrison, C
    Griffiths, M
    Bown, N
    Affiliation
    School of Biochemistry and Genetics, University of Newcastle upon Tyne, UK.
    Issue Date
    2000-11
    
    Metadata
    Show full item record
    Abstract
    The MLL gene, located at 11q23, is frequently rearranged in acute leukaemia as either chimaeric fusion genes or partial tandem duplications. We report a series of 12 acute leukaemia cases with apparent amplification of the MLL gene ascertained using fluorescence in situ hybridisation (FISH). Seven cases showed intrachromosomal amplification of MLL, four cases showed extrachromosomal amplification as double minute chromosomes (dmin) and one case had separate subclones with dmin and homogenously staining region (hsr). Southern blot analysis of the MLL gene showed MLL gene rearrangement in three of the 10 successful cases. These cases do not naturally fall into either of the two recognised categories of MLL rearrangement and may represent a third variety of MLL gene abnormalities.
    Citation
    MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study. 2000, 14 (11):1885-91 Leukemia
    Journal
    Leukemia
    URI
    http://hdl.handle.net/10541/86442
    PubMed ID
    11069023
    Type
    Article
    Language
    en
    ISSN
    0887-6924
    Collections
    All Christie Publications

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