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dc.contributor.authorClark, R
dc.contributor.authorByatt, S A
dc.contributor.authorBennett, C F
dc.contributor.authorBrama, M
dc.contributor.authorMartineau, M
dc.contributor.authorMoorman, A V
dc.contributor.authorRoberts, K
dc.contributor.authorSecker-Walker, L M
dc.contributor.authorRichards, S
dc.contributor.authorEden, Tim O B
dc.contributor.authorGoldstone, Anthony H
dc.contributor.authorHarrison, Christine J
dc.date.accessioned2009-11-18T12:00:39Z
dc.date.available2009-11-18T12:00:39Z
dc.date.issued2000-02
dc.identifier.citationMonosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia. 2000, 14 (2):241-6 Leukemiaen
dc.identifier.issn0887-6924
dc.identifier.pmid10673740
dc.identifier.urihttp://hdl.handle.net/10541/86383
dc.description.abstractTwenty new cases of acute lymphoblastic leukemia (ALL) with the dicentric chromosome dic(9;20)(p1113;q11) are presented. This chromosomal abnormality is difficult to identify from G-banding alone. It masquerades as monosomy 20 and is only accurately identified by fluorescence in situ hybridization (FISH). Monosomy 20 was found in 59/2790 patients with successful karyotypes entered to the Leukaemia Research Fund/UK Cancer Cytogenetics Group Karyotype Database in ALL (LRF/UKCCG Karyotype Database). FISH revealed dic(9;20) in 20/25 cases with available material. Extra copies of chromosome 21 were found in 8 of the 20 cases. Patients were 14 females and six males, aged 1-32 years (median 4 years), with leukocyte counts of 2-536 (median 23) x 109/l and immunophenotypes of common or pre-B ALL (17 cases), T-ALL (one case) or unknown (two cases). Four patients relapsed at 2, 22, 28 and 47 months and two died at 49 and 63 months (median follow-up 37 months). FISH studies on the remaining five patients showed one with monosomy 20 and four with other rearrangements of the chromosome. This study has increased the number of reported cases of dic(9;20) from 17 to 37. It has identified dic(9;20) in one case of T-ALL and shows an association of this translocation with trisomy 21.
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshChromosomes, Human, Pair 20
dc.subject.meshChromosomes, Human, Pair 9
dc.subject.meshDisease-Free Survival
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunophenotyping
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshInfant
dc.subject.meshKaryotyping
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMonosomy
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshSurvival Analysis
dc.subject.meshTranslocation, Genetic
dc.titleMonosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia.en
dc.typeArticleen
dc.contributor.departmentLeukaemia Research Fund/United Kingdom Cancer Cytogenetics Group Karyotype Database in Acute Lymphoblastic Leukaemia, Department of Haematology, Royal Free and University College Medical School, London, UK.en
dc.identifier.journalLeukemiaen
html.description.abstractTwenty new cases of acute lymphoblastic leukemia (ALL) with the dicentric chromosome dic(9;20)(p1113;q11) are presented. This chromosomal abnormality is difficult to identify from G-banding alone. It masquerades as monosomy 20 and is only accurately identified by fluorescence in situ hybridization (FISH). Monosomy 20 was found in 59/2790 patients with successful karyotypes entered to the Leukaemia Research Fund/UK Cancer Cytogenetics Group Karyotype Database in ALL (LRF/UKCCG Karyotype Database). FISH revealed dic(9;20) in 20/25 cases with available material. Extra copies of chromosome 21 were found in 8 of the 20 cases. Patients were 14 females and six males, aged 1-32 years (median 4 years), with leukocyte counts of 2-536 (median 23) x 109/l and immunophenotypes of common or pre-B ALL (17 cases), T-ALL (one case) or unknown (two cases). Four patients relapsed at 2, 22, 28 and 47 months and two died at 49 and 63 months (median follow-up 37 months). FISH studies on the remaining five patients showed one with monosomy 20 and four with other rearrangements of the chromosome. This study has increased the number of reported cases of dic(9;20) from 17 to 37. It has identified dic(9;20) in one case of T-ALL and shows an association of this translocation with trisomy 21.


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