• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Keratinocyte growth factor increases hair follicle survival following cytotoxic insult.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Booth, Catherine
    Potten, Christopher S
    Affiliation
    CRC Epithelial Biology Group, Paterson Institute, Christie Hospital (NHS) Trust, Manchester, U.K. cbooth@picr.man.ac.uk
    Issue Date
    2000-04
    
    Metadata
    Show full item record
    Abstract
    Hair loss is a distressing side-effect of cancer therapy. Factors that might reduce this loss are therefore likely to improve patient well-being and reduce treatment refusal. Keratinocyte growth factor has been shown to regulate proliferation and differentiation in epithelial tissues and may regulate the clonogenic cells (stem cells) of the hair follicle. Using X-irradiation as a model cytotoxic agent we investigated whether keratinocyte growth factor pretreatment could increase hair follicle survival (by implication clonogen survival) and regeneration of differentiated progeny (a hair). Irradiated telogen follicle survival data were consistent with that published previously. Daily keratinocyte growth factor pretreatment increased hair survival during the first hair growth cycle, the level of protection having a slight radiation dose dependence. Protection was maintained after a second hair cycle, but at a lower level (hairs and follicles). Hairs irradiated in anagen and analyzed during the second cycle exhibited a similar level of protection. No difference in protection levels could be observed between mice treated either once or twice daily with keratinocyte growth factor. Results indicated approximately 10 extra hairs per mm2 (14.5% of unirradiated control) could survive the cytotoxic insult if pretreated with 12.5 microg keratinocyte growth factor. This could be doubled by a 10 x higher keratinocyte growth factor dose. The fact that protection was maintained during two cycles of hair growth indicated that the clonogenic cells had been protected. Keratinocyte growth factor pretreatment had no significant effect on the level of mitosis but increased the number of p21waf1 expressing cells. Intriguingly, the number of apoptotic fragments per follicle were transiently increased in the keratinocyte growth factor pretreated mice, although this effect was most pronounced in the upper half of the follicle bulb, i.e., above (rather than within) the germinal matrix.
    Citation
    Keratinocyte growth factor increases hair follicle survival following cytotoxic insult. 2000, 114 (4):667-73 J. Invest. Dermatol.
    Journal
    The Journal of Investigative Dermatology
    URI
    http://hdl.handle.net/10541/86360
    DOI
    10.1046/j.1523-1747.2000.00927.x
    PubMed ID
    10733671
    Type
    Article
    Language
    en
    ISSN
    0022-202X
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1523-1747.2000.00927.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Manipulation of outer root sheath cell survival perturbs the hair-growth cycle.
    • Authors: Pena JC, Kelekar A, Fuchs EV, Thompson CB
    • Issue date: 1999 Jul 1
    • Neural Stem Cells Restore Hair Growth Through Activation of the Hair Follicle Niche.
    • Authors: Hwang I, Choi KA, Park HS, Jeong H, Kim JO, Seol KC, Kwon HJ, Park IH, Hong S
    • Issue date: 2016
    • Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor.
    • Authors: Khan WB, Shui C, Ning S, Knox SJ
    • Issue date: 1997 Sep
    • Dual-mode regulation of hair growth cycle by two Fgf-5 gene products.
    • Authors: Suzuki S, Ota Y, Ozawa K, Imamura T
    • Issue date: 2000 Mar
    • Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice.
    • Authors: Sugaya K, Hirobe T
    • Issue date: 2014 Feb
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.