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    Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes in women with cervical neoplasia.

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    Authors
    Bontkes, Hetty J
    De Gruijl, Tanja D
    Van den Muysenberg, Adrie J
    Verheijen, René H
    Stukart, Marij J
    Meijer, Chris J L M
    Scheper, Rik J
    Stacey, Simon N
    Duggan-Keen, Margaret F
    Stern, Peter L
    Man, Stephen
    Borysiewicz, Leszek K
    Walboomers, Jan M
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    Affiliation
    Department of Pathology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, the Netherlands.
    Issue Date
    2000-10-01
    
    Metadata
    Show full item record
    Abstract
    Infection with oncogenic human papillomavirus (HPV) types is associated with the development of cervical neoplasia (CIN). The E6 and E7 oncoproteins are constitutively expressed in these lesions and are therefore putative targets for the immune response against HPV. The relation between HPV 16-specific memory cytotoxic T-cell precursor (mCTLp) activity to both oncoproteins and the natural course of cervical dysplasia was analyzed in 38 patients participating in a nonintervention cohort study of women with CIN and 11 HPV 16-positive cervical carcinoma patients. In a cross-sectional study at the end of follow-up prior to biopsy, 8 of 20 patients with a persistent HPV 16 infection had specific mCTLp against at least one of the two oncoproteins. By contrast, no specific mCTLp activity was detected in 11 HPV-negative patients or in 7 patients who had cleared an HPV 16 infection at the end of follow-up. However, 5 of 11 cervical carcinoma patients showed mCTLp activity against the E7 protein only. This study demonstrates that HPV 16 oncogene-specific mCTLp are present in women with HPV 16-positive CIN prior to any intervention. Since HPV-specific mCTLp were detected predominantly in women with high-grade lesions or invasive cervical carcinoma and not in women who cleared the virus, the role of naturally occurring mCTLp in the protection against HPV-associated cervical neoplasia remains to be established.
    Citation
    Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes in women with cervical neoplasia. 2000, 88 (1):92-8 Int. J. Cancer
    Journal
    International Journal of Cancer.
    URI
    http://hdl.handle.net/10541/86357
    PubMed ID
    10962445
    Type
    Article
    Language
    en
    ISSN
    0020-7136
    Collections
    All Paterson Institute for Cancer Research

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