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    Expression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell transplantation.

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    Authors
    Wang, X
    Clowes, C
    Duarte, R
    Pu, Qingqiu
    Affiliation
    School of Biological Science, The University of Manchester, UK.
    Issue Date
    2000-09
    
    Metadata
    Show full item record
    Abstract
    Quantitative expression of neutrophil CD11b/CD18 following chemotherapy (either conventional dose consolidation chemotherapy or high dose chemotherapy with autologous stem cell transplantation) was investigated during the early recovery phase (neutrophil count 0. 5-1.0x109/l) and at full recovery (neutrophil count 1.0-2.5x109/l) following treatment. CD11b/18 expression was normal in stem cell transplantation supported patients during both early and full neutrophil recovery. By contrast CD11b/CD18 expression was markedly decreased in patients who received chemotherapy without stem cell support. These results suggest that recovery of neutrophil count may not always coincide with recovery of neutrophil function and that G-CSF stimulated peripheral stem cell transplantation enhances neutrophil function post chemotherapy.
    Citation
    Expression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell transplantation. 2000, 17 (3):597-602 Int. J. Oncol.
    Journal
    International Journal of Oncology
    URI
    http://hdl.handle.net/10541/86190
    PubMed ID
    10938404
    Type
    Article
    Language
    en
    ISSN
    1019-6439
    Collections
    All Paterson Institute for Cancer Research

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