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dc.contributor.authorRobertson, J D
dc.contributor.authorTesta, Nydia G
dc.contributor.authorRussell, N H
dc.contributor.authorJackson, G
dc.contributor.authorParker, A N
dc.contributor.authorMilligan, D W
dc.contributor.authorStainer, C
dc.contributor.authorChakrabarti, S
dc.contributor.authorDougal, Mark
dc.contributor.authorChopra, Rajesh
dc.date.accessioned2009-11-10T10:43:34Z
dc.date.available2009-11-10T10:43:34Z
dc.date.issued2001-06
dc.identifier.citationAccelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant. 2001, 27 (12):1283-6 Bone Marrow Transplant.en
dc.identifier.issn0268-3369
dc.identifier.pmid11548846
dc.identifier.doi10.1038/sj.bmt.1703069
dc.identifier.urihttp://hdl.handle.net/10541/85767
dc.description.abstractTelomere shortening has been documented in the blood cells of recipients of allogeneic bone marrow transplants compared with their donors. Allogeneic peripheral blood progenitor cells (PBPCs) have been increasingly used as an alternative to bone marrow. Their advantages include earlier engraftment and immune reconstitution following transplantation. We have measured telomere length of neutrophils and T cells in fully engrafted recipients of allogeneic bone marrow (n = 19) and allogeneic PBPC (n = 17) and also measured sequential telomere length in four patients after transplantation. Overall, significant telomere shortening occurred in recipients in neutrophils (0.3 kb, P < 0.001) and T cells (0.2 kb, P = 0.045). The data demonstrate that first, the degree of shortening was the same for BM and PBPC transplants and was not related to the time taken to engraft neutrophils and platelets and second, telomere shortening occurs in the first year post transplant without further shortening during the period of observation. These data suggest that the superiority of engraftment seen in PBPC transplants is independent of telomere shortening and other mechanisms such as homing or seeding may be more important.
dc.language.isoenen
dc.subjectHaematopoietic Stem Cell Transplantationen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBlood Cells
dc.subject.meshBone Marrow Transplantation
dc.subject.meshGraft Survival
dc.subject.meshHematopoietic Stem Cell Transplantation
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshNeutrophils
dc.subject.meshT-Lymphocytes
dc.subject.meshTelomere
dc.subject.meshTime Factors
dc.subject.meshTransplantation, Homologous
dc.titleAccelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant.en
dc.typeArticleen
dc.contributor.departmentCRC Laboratory of Experimental Hematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBone Marrow Transplantationen
html.description.abstractTelomere shortening has been documented in the blood cells of recipients of allogeneic bone marrow transplants compared with their donors. Allogeneic peripheral blood progenitor cells (PBPCs) have been increasingly used as an alternative to bone marrow. Their advantages include earlier engraftment and immune reconstitution following transplantation. We have measured telomere length of neutrophils and T cells in fully engrafted recipients of allogeneic bone marrow (n = 19) and allogeneic PBPC (n = 17) and also measured sequential telomere length in four patients after transplantation. Overall, significant telomere shortening occurred in recipients in neutrophils (0.3 kb, P < 0.001) and T cells (0.2 kb, P = 0.045). The data demonstrate that first, the degree of shortening was the same for BM and PBPC transplants and was not related to the time taken to engraft neutrophils and platelets and second, telomere shortening occurs in the first year post transplant without further shortening during the period of observation. These data suggest that the superiority of engraftment seen in PBPC transplants is independent of telomere shortening and other mechanisms such as homing or seeding may be more important.


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