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dc.contributor.authorStern, Peter L
dc.contributor.authorFaulkner, Rebecca L
dc.contributor.authorVeranes, Emma C
dc.contributor.authorDavidson, Emma J
dc.date.accessioned2009-11-10T10:33:45Z
dc.date.available2009-11-10T10:33:45Z
dc.date.issued2001-10
dc.identifier.citationThe role of human papillomavirus vaccines in cervical neoplasia. 2001, 15 (5):783-99 Best Pract Res Clin Obstet Gynaecolen
dc.identifier.issn1521-6934
dc.identifier.pmid11563873
dc.identifier.doi10.1053/beog.2001.0220
dc.identifier.urihttp://hdl.handle.net/10541/85763
dc.description.abstractCervical cancer is the second most common cause of cancer-related death in women, in some developing countries accounting for the highest cancer mortality. The evidence for the association of high-risk human papillomavirus types with the aetiology of cervical neoplasia is firmly established, human papillomavirus being detected in virtually all cervical cancers. The risk of progression of precursor cervical intra-epithelial neoplasia lesions is associated with persistence of human papillomavirus infection. One strategy for the management of cervical neoplasia worldwide could be the development of prophylactic and/or therapeutic human papillomavirus vaccines. This chapter will discuss the natural history of human papillomavirus infection, viral immunity and the clinical course of resultant disease as the background to the effective design and use of human papillomavirus vaccines for protection or therapy. The progress of ongoing phase I and II clinical trials for several different vaccine preparations and the challenges for establishing their future use will be discussed.
dc.language.isoenen
dc.subjectTumour Virus Infectionsen
dc.subjectUterine Cervical Canceren
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshPapillomaviridae
dc.subject.meshPapillomavirus Infections
dc.subject.meshPapillomavirus Vaccines
dc.subject.meshTumor Virus Infections
dc.subject.meshUterine Cervical Neoplasms
dc.subject.meshViral Vaccines
dc.titleThe role of human papillomavirus vaccines in cervical neoplasia.en
dc.typeArticleen
dc.contributor.departmentImmunology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.en
dc.identifier.journalBest Practice & Research. Clinical Obstetrics & Gynaecologyen
html.description.abstractCervical cancer is the second most common cause of cancer-related death in women, in some developing countries accounting for the highest cancer mortality. The evidence for the association of high-risk human papillomavirus types with the aetiology of cervical neoplasia is firmly established, human papillomavirus being detected in virtually all cervical cancers. The risk of progression of precursor cervical intra-epithelial neoplasia lesions is associated with persistence of human papillomavirus infection. One strategy for the management of cervical neoplasia worldwide could be the development of prophylactic and/or therapeutic human papillomavirus vaccines. This chapter will discuss the natural history of human papillomavirus infection, viral immunity and the clinical course of resultant disease as the background to the effective design and use of human papillomavirus vaccines for protection or therapy. The progress of ongoing phase I and II clinical trials for several different vaccine preparations and the challenges for establishing their future use will be discussed.


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