Affiliation
Immunology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.Issue Date
2001-10
Metadata
Show full item recordAbstract
Cervical cancer is the second most common cause of cancer-related death in women, in some developing countries accounting for the highest cancer mortality. The evidence for the association of high-risk human papillomavirus types with the aetiology of cervical neoplasia is firmly established, human papillomavirus being detected in virtually all cervical cancers. The risk of progression of precursor cervical intra-epithelial neoplasia lesions is associated with persistence of human papillomavirus infection. One strategy for the management of cervical neoplasia worldwide could be the development of prophylactic and/or therapeutic human papillomavirus vaccines. This chapter will discuss the natural history of human papillomavirus infection, viral immunity and the clinical course of resultant disease as the background to the effective design and use of human papillomavirus vaccines for protection or therapy. The progress of ongoing phase I and II clinical trials for several different vaccine preparations and the challenges for establishing their future use will be discussed.Citation
The role of human papillomavirus vaccines in cervical neoplasia. 2001, 15 (5):783-99 Best Pract Res Clin Obstet GynaecolJournal
Best Practice & Research. Clinical Obstetrics & GynaecologyDOI
10.1053/beog.2001.0220PubMed ID
11563873Type
ArticleLanguage
enISSN
1521-6934ae974a485f413a2113503eed53cd6c53
10.1053/beog.2001.0220
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