AffiliationImmunology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.
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AbstractCervical cancer is the second most common cause of cancer-related death in women, in some developing countries accounting for the highest cancer mortality. The evidence for the association of high-risk human papillomavirus types with the aetiology of cervical neoplasia is firmly established, human papillomavirus being detected in virtually all cervical cancers. The risk of progression of precursor cervical intra-epithelial neoplasia lesions is associated with persistence of human papillomavirus infection. One strategy for the management of cervical neoplasia worldwide could be the development of prophylactic and/or therapeutic human papillomavirus vaccines. This chapter will discuss the natural history of human papillomavirus infection, viral immunity and the clinical course of resultant disease as the background to the effective design and use of human papillomavirus vaccines for protection or therapy. The progress of ongoing phase I and II clinical trials for several different vaccine preparations and the challenges for establishing their future use will be discussed.
CitationThe role of human papillomavirus vaccines in cervical neoplasia. 2001, 15 (5):783-99 Best Pract Res Clin Obstet Gynaecol
JournalBest Practice & Research. Clinical Obstetrics & Gynaecology
- [Prophylactic and therapeutic vaccine therapy in papillomavirus infections].
- Authors: Vinatier D, Cosson M, Dufour P
- Issue date: 2000 May
- Anti human papillomavirus vaccine: the checkmate to human papillomavirus?
- Authors: Moscarini M, Lukic A, Franco C
- Issue date: 2004
- [Human papillomavirus prophylactic vaccines: stakes and perspectives].
- Authors: Hantz S, Alain S, Denis F
- Issue date: 2006 Jul-Aug
- The impact of anti HPV vaccination on cervical cancer incidence and HPV induced cervical lesions: consequences for clinical management.
- Authors: Brinkman JA, Caffrey AS, Muderspach LI, Roman LD, Kast WM
- Issue date: 2005
- [Viruses and cervical cancers].
- Authors: Mathevet P
- Issue date: 2001 Sep 1