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    Redox control of AP-1-like factors in yeast and beyond.

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    Authors
    Toone, W Mark
    Morgan, Brian A
    Jones, Nic
    Affiliation
    CRC Cell Regulation Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2001-04-30
    
    Metadata
    Show full item record
    Abstract
    Cells have evolved complex and efficient strategies for dealing with variable and often-harsh environments. A key aspect of these stress responses is the transcriptional activation of genes encoding defense and repair proteins. In yeast members of the AP-1 family of proteins are required for the transcriptional response to oxidative stress. This sub-family of AP-1 (called yAP-1) proteins are sensors of the redox-state of the cell and are activated directly by oxidative stress conditions. yAP-1 proteins are bZIP-containing factors that share homology to the mammalian AP-1 factor complex and bind to very similar DNA sequence sites. The generation of reactive oxygen species and the resulting potential for oxidative stress is common to all aerobically growing organisms. Furthermore, many of the features of this response appear to be evolutionarily conserved and consequently the study of model organisms, such as yeast, will have widespread utility. The important structural features of these factors, signaling pathways controlling their activity and the nature of the target genes they control will be discussed.
    Citation
    Redox control of AP-1-like factors in yeast and beyond. 2001, 20 (19):2336-46 Oncogene
    Journal
    Oncogene
    URI
    http://hdl.handle.net/10541/85740
    DOI
    10.1038/sj.onc.1204384
    PubMed ID
    11402331
    Type
    Article
    Language
    en
    ISSN
    0950-9232
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.onc.1204384
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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