Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population.
Affiliation
School of Epidemiology and Health Sciences, Medical School, University of Manchester, Oxford Road, Manchester M139PT, UK.Issue Date
2001-11
Metadata
Show full item recordAbstract
NAD(P)H: quinone oxidoreductase (NQO1) protects the cell against cytotoxicity by reducing the concentration of free quinone available for single electron reduction. The NQO1 gene is polymorphic and the variant protein exhibits just 2% of the enzymatic activity of the wildtype protein. In this study, we investigated NQO1 genotype in relation to lung cancer risk in patients attending a Manchester bronchoscopy clinic. The cases were patients with a current, or history of, malignant tumour of the lung, trachea or bronchus. The control group were all other patients attending the clinic who had never been diagnosed with a tumour. DNA extraction from bronchial lavage or blood samples and genotyping was successfully carried out for 82 of the cases and 145 controls. Patients carrying at least one variant allele were found to have almost a 4-fold increased risk of developing small cell lung cancer (adjusted OR=3.80, 95% C.I. 1.19-12.1). No association between NQO1 genotypes and non-small cell lung cancer risk was found. Furthermore, the excess small cell lung cancer risk associated with non-wildtype NQO1 genotypes was only apparent in heavy smokers where there was a >10-fold increased risk (adjusted OR=12.5, 95% C.I. 2.1-75.5). These results suggest that the NQO1 protein may be involved in the detoxification of those carcinogens associated with the development of small cell lung cancer. Individuals with reduced enzyme activity, due to a polymorphism in this gene, may therefore have an increased risk of developing this disease.Citation
Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population. 2001, 34 (2):177-83 Lung CancerJournal
Lung CancerPubMed ID
11679176Type
ArticleLanguage
enISSN
0169-5002Collections
Related articles
- An association between a NQO1 genetic polymorphism and risk of lung cancer.
- Authors: Saldivar SJ, Wang Y, Zhao H, Shao L, Lin J, Spitz MR, Wu X
- Issue date: 2005 Apr 4
- Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H: quinone oxidoreductase polymorphism.
- Authors: Wiencke JK, Spitz MR, McMillan A, Kelsey KT
- Issue date: 1997 Feb
- The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking behavior.
- Authors: Xu LL, Wain JC, Miller DP, Thurston SW, Su L, Lynch TJ, Christiani DC
- Issue date: 2001 Apr
- NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis.
- Authors: Chao C, Zhang ZF, Berthiller J, Boffetta P, Hashibe M
- Issue date: 2006 May
- NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism.
- Authors: Jamieson D, Wilson K, Pridgeon S, Margetts JP, Edmondson RJ, Leung HY, Knox R, Boddy AV
- Issue date: 2007 Mar 1