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dc.contributor.authorO'Connor, Peter Jen
dc.contributor.authorMacNaught, Fen
dc.contributor.authorButler, W Hen
dc.contributor.authorCooper, Donald Pen
dc.contributor.authorMargison, Geoffrey Pen
dc.contributor.authorPovey, Andrew Cen
dc.date.accessioned2009-11-10T09:48:20Z
dc.date.available2009-11-10T09:48:20Z
dc.date.issued2001
dc.identifier.citationIncreased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine. 2001, 20 (3):223-7 J. Environ. Pathol. Toxicol. Oncol.en
dc.identifier.issn0731-8898
dc.identifier.pmid11797831
dc.identifier.urihttp://hdl.handle.net/10541/85724
dc.description.abstractIvermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) by gavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the forestomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.
dc.language.isoenen
dc.subjectStomach Canceren
dc.subject.meshAdministration, Oral
dc.subject.meshAnimals
dc.subject.meshDiet
dc.subject.meshDrug Interactions
dc.subject.meshInsecticides
dc.subject.meshIvermectin
dc.subject.meshMale
dc.subject.meshMethylnitronitrosoguanidine
dc.subject.meshMutagens
dc.subject.meshPrecancerous Conditions
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshSeverity of Illness Index
dc.subject.meshStomach Neoplasms
dc.titleIncreased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalJournal of Environmental Pathology, Toxicology and Oncologyen
html.description.abstractIvermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) by gavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the forestomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.


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