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    Increased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine.

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    Authors
    O'Connor, Peter J
    MacNaught, F
    Butler, W H
    Cooper, Donald P
    Margison, Geoffrey P
    Povey, Andrew C
    Affiliation
    Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    2001
    
    Metadata
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    Abstract
    Ivermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) by gavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the forestomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.
    Citation
    Increased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine. 2001, 20 (3):223-7 J. Environ. Pathol. Toxicol. Oncol.
    Journal
    Journal of Environmental Pathology, Toxicology and Oncology
    URI
    http://hdl.handle.net/10541/85724
    PubMed ID
    11797831
    Type
    Article
    Language
    en
    ISSN
    0731-8898
    Collections
    All Paterson Institute for Cancer Research

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