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dc.contributor.authorLawrence, Nicholas J
dc.contributor.authorMcGown, Alan T
dc.contributor.authorNduka, Jane
dc.contributor.authorHadfield, John A
dc.contributor.authorPritchard, Robin G
dc.date.accessioned2009-11-10T09:33:21Z
dc.date.available2009-11-10T09:33:21Z
dc.date.issued2001-02-12
dc.identifier.citationCytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. 2001, 11 (3):429-31 Bioorg. Med. Chem. Lett.en
dc.identifier.issn0960-894X
dc.identifier.pmid11212128
dc.identifier.urihttp://hdl.handle.net/10541/85719
dc.description.abstractTwo series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.
dc.language.isoenen
dc.subjectCultured Tumour Cellsen
dc.subject.meshAmines
dc.subject.meshAntineoplastic Agents
dc.subject.meshApoptosis
dc.subject.meshCell Cycle
dc.subject.meshCell Division
dc.subject.meshCombinatorial Chemistry Techniques
dc.subject.meshHumans
dc.subject.meshInhibitory Concentration 50
dc.subject.meshK562 Cells
dc.subject.meshLactones
dc.subject.meshStructure-Activity Relationship
dc.subject.meshTumor Cells, Cultured
dc.titleCytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uken
dc.identifier.journalBioorganic & Medicinal Chemistry Lettersen
html.description.abstractTwo series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.


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