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    Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.

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    Authors
    Lawrence, Nicholas J
    McGown, Alan T
    Nduka, Jane
    Hadfield, John A
    Pritchard, Robin G
    Affiliation
    Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uk
    Issue Date
    2001-02-12
    
    Metadata
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    Abstract
    Two series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.
    Citation
    Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. 2001, 11 (3):429-31 Bioorg. Med. Chem. Lett.
    Journal
    Bioorganic & Medicinal Chemistry Letters
    URI
    http://hdl.handle.net/10541/85719
    PubMed ID
    11212128
    Type
    Article
    Language
    en
    ISSN
    0960-894X
    Collections
    All Paterson Institute for Cancer Research

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