Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.
Affiliation
Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.ukIssue Date
2001-02-12
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Show full item recordAbstract
Two series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.Citation
Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. 2001, 11 (3):429-31 Bioorg. Med. Chem. Lett.Journal
Bioorganic & Medicinal Chemistry LettersPubMed ID
11212128Type
ArticleLanguage
enISSN
0960-894XCollections
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