Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.
Affiliation
Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.ukIssue Date
2001-02-12
Metadata
Show full item recordAbstract
Two series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.Citation
Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. 2001, 11 (3):429-31 Bioorg. Med. Chem. Lett.Journal
Bioorganic & Medicinal Chemistry LettersPubMed ID
11212128Type
ArticleLanguage
enISSN
0960-894XCollections
Related articles
- Synthesis and biological properties of new alpha-methylene-gamma-butyrolactones and alpha,beta-unsaturated delta-lactones.
- Authors: Cateni F, Zilic J, Zacchigna M, Bonivento P, Frausin F, Scarcia V
- Issue date: 2006 Feb
- Antitumor agents. 3. Synthesis and cytotoxic activity of helenalin amine adducts and related derivatives.
- Authors: Lee KH, Furukawa H
- Issue date: 1972 Jun
- Steroidal alpha-methylene delta-lactones as potential antitumor agents.
- Authors: Dehal SS, Marples BA, Stretton RJ, Traynor JR
- Issue date: 1980 Jan
- 4-Methylideneisoxazolidin-5-ones--a new class of alpha-methylidene-gamma-lactones with high cytostatic activity.
- Authors: Janecki T, Wasek T, Rózalski M, Krajewska U, Studzian K, Janecka A
- Issue date: 2006 Mar 1
- Gamma-lactones alpha,beta- and beta,gamma-fused to carbocycles as novel antiproliferative drugs.
- Authors: León LG, Machín RP, Rodríguez CM, Ravelo JL, Martín VS, Padrón JM
- Issue date: 2008 Oct 1