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    Cyclin-mediated export of human Orc1.

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    Authors
    Laman, Heike
    Peters, Gordon
    Jones, Nic
    Affiliation
    Molecular Oncology Laboratory, Gene Regulation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London, WC2A 3PX, United Kingdom.
    Issue Date
    2001-12-10
    
    Metadata
    Show full item record
    Abstract
    Viral cyclin/cdk6 complexes interact with and phosphorylate human Orc1, a component of the origin recognition complex (ORC) that functions in DNA replication. Here we assess the effect that viral cyclin has on the intracellular location of human Orc1, which is present in both nuclear and cytoplasmic pools. Overexpression of K cyclin or cyclin A results in Crm1-dependent export of Orc1 to the cytoplasm, and this process is dependent on the phosphorylation status of several cdk target sites in Orc1. These findings support a model where S phase promoting cyclin activity drives the export of a component of replication complexes.
    Citation
    Cyclin-mediated export of human Orc1. 2001, 271 (2):230-7 Exp. Cell Res.
    Journal
    Experimental Cell Research
    URI
    http://hdl.handle.net/10541/85615
    DOI
    10.1006/excr.2001.5360
    PubMed ID
    11716535
    Type
    Article
    Language
    en
    ISSN
    0014-4827
    ae974a485f413a2113503eed53cd6c53
    10.1006/excr.2001.5360
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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