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    Transgenerational effects of preconception paternal contamination with (55)Fe.

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    Authors
    Hoyes, Katherine P
    Lord, Brian I
    McCann, Christine
    Hendry, Jolyon H
    Morris, Ian D
    Affiliation
    Cancer Research Campaign Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, M20 4BX, United Kingdom.
    Issue Date
    2001-11
    
    Metadata
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    Abstract
    The conjecture that germline mutations induced by radiation exposure before conception may predispose subsequent offspring to cancer remains contentious. Previous experimental studies have shown that preconception paternal irradiation with (239)Pu induces perturbations in the hemopoietic systems of offspring and influences sensitivity to a secondary carcinogen. In the present study, male DBA2 mice were injected intravenously with the Auger electron emitter (55)Fe (4 kBq g(-1)) 18 or 84 days before mating with normal females. Comet analysis showed an increased incidence of DNA strand breaks in sperm from contaminated animals after 84 days, but not after 18 days, indicating spermatogonial rather than spermatid damage. Offspring were either assayed for changes in bone marrow stem cells and committed progenitors or challenged with the chemical carcinogen methyl nitrosourea (MNU, 50 mg/kg) at 10 weeks of age and monitored for the onset of malignancy. Offspring from irradiated fathers had normal peripheral blood profiles, although the stem cell population was amplified in offspring arising from those exposed to (55)Fe at 84 days before conception. Exposure to MNU significantly increased the incidence of lympho-hemopoietic malignancies in offspring from the 84-day group, but not in those from the 18-day group. These findings support the hypothesis that aberrations that are potentially leukemogenic may be transmitted to offspring after radiation damage to the paternal germline.
    Citation
    Transgenerational effects of preconception paternal contamination with (55)Fe. 2001, 156 (5 Pt 1):488-94 Radiat. Res.
    Journal
    Radiation Research
    URI
    http://hdl.handle.net/10541/85614
    PubMed ID
    11604061
    Type
    Article
    Language
    en
    ISSN
    0033-7587
    Collections
    All Paterson Institute for Cancer Research

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