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    Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication.

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    Authors
    Laman, Heike
    Coverley, Dawn
    Krude, Torsten
    Laskey, Ronald
    Jones, Nic
    Affiliation
    Gene Regulation Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom.
    Issue Date
    2001-01
    
    Metadata
    Show full item record
    Abstract
    The cyclins encoded by Kaposi sarcoma-associated herpesvirus and herpesvirus saimiri are homologs of human D-type cyclins. However, when complexed to cdk6, they have several activities that distinguish them from D-type cyclin-cdk6 complexes, including resistance to cyclin-dependent kinase inhibitors and an enhanced substrate range. We find that viral cyclins interact with and phosphorylate proteins involved in replication initiation. Using mammalian in vitro replication systems, we show that viral cyclin-cdk6 complexes can directly trigger the initiation of DNA synthesis in isolated late-G(1)-phase nuclei. Viral cyclin-cdk6 complexes share this capacity with cyclin A-cdk2, demonstrating that in addition to functioning as G(1)-phase cyclin-cdk complexes, they function as S-phase cyclin-cdk complexes.
    Citation
    Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication. 2001, 21 (2):624-35 Mol. Cell. Biol.
    Journal
    Molecular and Cellular Biology
    URI
    http://hdl.handle.net/10541/85609
    DOI
    10.1128/MCB.21.2.624-635.2001
    PubMed ID
    11134348
    Type
    Article
    Language
    en
    ISSN
    0270-7306
    ae974a485f413a2113503eed53cd6c53
    10.1128/MCB.21.2.624-635.2001
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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