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dc.contributor.authorKim, Joo-Young
dc.contributor.authorCho, Hyun Yee
dc.contributor.authorLee, Kyu Chan
dc.contributor.authorHwang, You Jin
dc.contributor.authorLee, Myung Hak
dc.contributor.authorRoberts, Stephen A
dc.contributor.authorKim, Chul-Hwan
dc.date.accessioned2009-11-06T16:49:44Z
dc.date.available2009-11-06T16:49:44Z
dc.date.issued2001-10-20
dc.identifier.citationTumor apoptosis in cervical cancer: its role as a prognostic factor in 42 radiotherapy patients. 2001, 96 (5):305-12 Int. J. Canceren
dc.identifier.issn0020-7136
dc.identifier.pmid11582583
dc.identifier.urihttp://hdl.handle.net/10541/85607
dc.description.abstractTo investigate tumor apoptosis as a prognostic factor for outcome following radiation therapy, comparisons were made of apoptotic index (AI) as a predictor of short- vs. long-term response and pretreatment vs. radiation-induced apoptosis. Forty-two patients with proven squamous cell carcinoma of the uterine cervix were treated by radiation alone. Apoptosis was measured by light microscopic observation of hematoxylin and eosin-stained sections from biopsies taken before treatment and 4 and 24 hr after 2 Gy. Patients were evaluated at the end of the external radiation for determination of short-term response and for long-term outcome as well (median follow-up of 27 months). Patients with high spontaneous AI showed poor short-term response, local control, and survival. The significance of AI as a predictor of short-term response was lost after allowing for differences in tumor size. The positive predictive value of AI for local control and survival was independent of tumor size and stage. High AI was associated with poor local control and long-term prognosis in advanced squamous cell carcinoma of the cervix. The in vivo radiation-induced AI after 4 or 24 hr did not predict radiation therapy outcome.
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshApoptosis
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshDisease-Free Survival
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMiddle Aged
dc.subject.meshPrognosis
dc.subject.meshTime Factors
dc.subject.meshTreatment Outcome
dc.subject.meshUterine Cervical Neoplasms
dc.titleTumor apoptosis in cervical cancer: its role as a prognostic factor in 42 radiotherapy patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, Gil Medical Center, Gachon Medical College, Inchon, Korea.en
dc.identifier.journalInternational Journal of Canceren
html.description.abstractTo investigate tumor apoptosis as a prognostic factor for outcome following radiation therapy, comparisons were made of apoptotic index (AI) as a predictor of short- vs. long-term response and pretreatment vs. radiation-induced apoptosis. Forty-two patients with proven squamous cell carcinoma of the uterine cervix were treated by radiation alone. Apoptosis was measured by light microscopic observation of hematoxylin and eosin-stained sections from biopsies taken before treatment and 4 and 24 hr after 2 Gy. Patients were evaluated at the end of the external radiation for determination of short-term response and for long-term outcome as well (median follow-up of 27 months). Patients with high spontaneous AI showed poor short-term response, local control, and survival. The significance of AI as a predictor of short-term response was lost after allowing for differences in tumor size. The positive predictive value of AI for local control and survival was independent of tumor size and stage. High AI was associated with poor local control and long-term prognosis in advanced squamous cell carcinoma of the cervix. The in vivo radiation-induced AI after 4 or 24 hr did not predict radiation therapy outcome.


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