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dc.contributor.authorBooth, Dawn
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2009-11-06T16:02:58Z
dc.date.available2009-11-06T16:02:58Z
dc.date.issued2001
dc.identifier.citationProtection against mucosal injury by growth factors and cytokines. 2001 (29):16-20 J. Natl. Cancer Inst. Monographsen
dc.identifier.issn1052-6773
dc.identifier.pmid11694560
dc.identifier.urihttp://hdl.handle.net/10541/85597
dc.description.abstractThis article provides an overview of published studies in which growth factors and cytokines were used to modify the sensitivity of intestinal stem cells to a dose of radiation. In these experiments, growth factors were used to manipulate the sensitivity of stem cells in the gastrointestinal tract to reduce the severity of gastrointestinal mucositis in cancer therapy patients. Transforming growth factor beta3, interleukin 11, and keratinocyte growth factor were used. All three agents, given according to appropriate protocols, can result in a threefold to fourfold increase in the number of intestinal stem cells that survive a dose of radiation therapy. This result was assessed by using the crypt microcolony assay of stem cell functional capacity. The changes in stem cell survival that were observed resulted in increased animal survival. This increased survival was taken as a surrogate for improvement in patient well-being. The severity of diarrhea, a marker of functional impairment, was concomitantly reduced.
dc.language.isoenen
dc.subjectDiarrhoeaen
dc.subject.meshAnimals
dc.subject.meshCell Survival
dc.subject.meshCytokines
dc.subject.meshDiarrhea
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshFibroblast Growth Factor 7
dc.subject.meshFibroblast Growth Factors
dc.subject.meshGrowth Substances
dc.subject.meshHumans
dc.subject.meshInterleukin-11
dc.subject.meshMice
dc.subject.meshMice, Inbred C57BL
dc.subject.meshMucous Membrane
dc.subject.meshRadiotherapy
dc.subject.meshStem Cells
dc.subject.meshTime Factors
dc.subject.meshTransforming Growth Factor beta
dc.subject.meshTransforming Growth Factor beta3
dc.titleProtection against mucosal injury by growth factors and cytokines.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Epithelial Biology Group, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalJournal of the National Cancer Institute. Monographsen
html.description.abstractThis article provides an overview of published studies in which growth factors and cytokines were used to modify the sensitivity of intestinal stem cells to a dose of radiation. In these experiments, growth factors were used to manipulate the sensitivity of stem cells in the gastrointestinal tract to reduce the severity of gastrointestinal mucositis in cancer therapy patients. Transforming growth factor beta3, interleukin 11, and keratinocyte growth factor were used. All three agents, given according to appropriate protocols, can result in a threefold to fourfold increase in the number of intestinal stem cells that survive a dose of radiation therapy. This result was assessed by using the crypt microcolony assay of stem cell functional capacity. The changes in stem cell survival that were observed resulted in increased animal survival. This increased survival was taken as a surrogate for improvement in patient well-being. The severity of diarrhea, a marker of functional impairment, was concomitantly reduced.


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