• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Protection against mucosal injury by growth factors and cytokines.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Booth, Dawn
    Potten, Christopher S
    Affiliation
    Cancer Research Campaign Epithelial Biology Group, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
    Issue Date
    2001
    
    Metadata
    Show full item record
    Abstract
    This article provides an overview of published studies in which growth factors and cytokines were used to modify the sensitivity of intestinal stem cells to a dose of radiation. In these experiments, growth factors were used to manipulate the sensitivity of stem cells in the gastrointestinal tract to reduce the severity of gastrointestinal mucositis in cancer therapy patients. Transforming growth factor beta3, interleukin 11, and keratinocyte growth factor were used. All three agents, given according to appropriate protocols, can result in a threefold to fourfold increase in the number of intestinal stem cells that survive a dose of radiation therapy. This result was assessed by using the crypt microcolony assay of stem cell functional capacity. The changes in stem cell survival that were observed resulted in increased animal survival. This increased survival was taken as a surrogate for improvement in patient well-being. The severity of diarrhea, a marker of functional impairment, was concomitantly reduced.
    Citation
    Protection against mucosal injury by growth factors and cytokines. 2001 (29):16-20 J. Natl. Cancer Inst. Monographs
    Journal
    Journal of the National Cancer Institute. Monographs
    URI
    http://hdl.handle.net/10541/85597
    PubMed ID
    11694560
    Type
    Article
    Language
    en
    ISSN
    1052-6773
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor.
    • Authors: Khan WB, Shui C, Ning S, Knox SJ
    • Issue date: 1997 Sep
    • Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo.
    • Authors: Potten CS, Booth D, Haley JD
    • Issue date: 1997
    • Transforming growth factor-B3 protects murine small intestinal crypt stem cells and animal survival after irradiation, possibly by reducing stem-cell cycling.
    • Authors: Booth D, Haley JD, Bruskin AM, Potten CS
    • Issue date: 2000 Apr 1
    • Keratinocyte growth factor increases hair follicle survival following cytotoxic insult.
    • Authors: Booth C, Potten CS
    • Issue date: 2000 Apr
    • Interleukin-11 protects the clonogenic stem cells in murine small-intestinal crypts from impairment of their reproductive capacity by radiation.
    • Authors: Potten CS
    • Issue date: 1995 Jul 28
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.