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dc.contributor.authorLawrence, Nicholas J
dc.contributor.authorRennison, David
dc.contributor.authorWoo, Meiki
dc.contributor.authorMcGown, Alan T
dc.contributor.authorHadfield, John A
dc.date.accessioned2009-11-06T16:42:26Z
dc.date.available2009-11-06T16:42:26Z
dc.date.issued2001-01-08
dc.identifier.citationAntimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. 2001, 11 (1):51-4 Bioorg. Med. Chem. Lett.en
dc.identifier.issn0960-894X
dc.identifier.pmid11140732
dc.identifier.urihttp://hdl.handle.net/10541/85591
dc.description.abstractA series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
dc.language.isoenen
dc.subjectCultured Tumour Cellsen
dc.subject.meshAntineoplastic Agents
dc.subject.meshAntineoplastic Agents, Phytogenic
dc.subject.meshCell Cycle
dc.subject.meshCell Division
dc.subject.meshColchicine
dc.subject.meshEthers
dc.subject.meshHumans
dc.subject.meshInhibitory Concentration 50
dc.subject.meshMolecular Structure
dc.subject.meshPlants, Medicinal
dc.subject.meshProtein Binding
dc.subject.meshStilbenes
dc.subject.meshTubulin
dc.subject.meshTumor Cells, Cultured
dc.titleAntimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uken
dc.identifier.journalBioorganic & Medicinal Chemistry Lettersen
html.description.abstractA series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.


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