Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
dc.contributor.author | Lawrence, Nicholas J | |
dc.contributor.author | Rennison, David | |
dc.contributor.author | Woo, Meiki | |
dc.contributor.author | McGown, Alan T | |
dc.contributor.author | Hadfield, John A | |
dc.date.accessioned | 2009-11-06T16:42:26Z | |
dc.date.available | 2009-11-06T16:42:26Z | |
dc.date.issued | 2001-01-08 | |
dc.identifier.citation | Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. 2001, 11 (1):51-4 Bioorg. Med. Chem. Lett. | en |
dc.identifier.issn | 0960-894X | |
dc.identifier.pmid | 11140732 | |
dc.identifier.uri | http://hdl.handle.net/10541/85591 | |
dc.description.abstract | A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest. | |
dc.language.iso | en | en |
dc.subject | Cultured Tumour Cells | en |
dc.subject.mesh | Antineoplastic Agents | |
dc.subject.mesh | Antineoplastic Agents, Phytogenic | |
dc.subject.mesh | Cell Cycle | |
dc.subject.mesh | Cell Division | |
dc.subject.mesh | Colchicine | |
dc.subject.mesh | Ethers | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Inhibitory Concentration 50 | |
dc.subject.mesh | Molecular Structure | |
dc.subject.mesh | Plants, Medicinal | |
dc.subject.mesh | Protein Binding | |
dc.subject.mesh | Stilbenes | |
dc.subject.mesh | Tubulin | |
dc.subject.mesh | Tumor Cells, Cultured | |
dc.title | Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. | en |
dc.type | Article | en |
dc.contributor.department | Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uk | en |
dc.identifier.journal | Bioorganic & Medicinal Chemistry Letters | en |
html.description.abstract | A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest. |