Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Affiliation
Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.ukIssue Date
2001-01-08
Metadata
Show full item recordAbstract
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.Citation
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. 2001, 11 (1):51-4 Bioorg. Med. Chem. Lett.Journal
Bioorganic & Medicinal Chemistry LettersPubMed ID
11140732Type
ArticleLanguage
enISSN
0960-894XCollections
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