• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Linked parallel synthesis and MTT bioassay screening of substituted chalcones.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Lawrence, Nicholas J
    Rennison, David
    McGown, Alan T
    Ducki, Sylvie W
    Gul, Lubna A
    Hadfield, John A
    Khan, Nader
    Affiliation
    Department of Chemistry, University of Manchester Institute of Science and Technology, P.O. Box 88, Manchester, M60 1QD, UK. Lawrencenj1@cardiff.ac.uk
    Issue Date
    2001
    
    Metadata
    Show full item record
    Abstract
    A 644-membered library of chalcones was prepared by parallel synthesis using the Claisen-Schmidt base-catalyzed aldol condensation of substituted acetophenones and benzaldehydes. The cytotoxicity of these chalcones was conveniently determined upon the crude products directly in 96-well microtiter test plates by the conventional MTT assay. This method revealed seven chalcones of IC(50) less than 1 microM of which 4'-hydroxy-2,4,6,3'-tetramethoxychalcone (5a) was the most active [IC(50) (K562), 30 nM]; it causes cell cycle arrest at the G(2)/M point and binds to tubulin at the colchicine binding site.
    Citation
    Linked parallel synthesis and MTT bioassay screening of substituted chalcones., 3 (5):421-6 J Comb Chem
    Journal
    Journal of Combinatorial Chemistry
    URI
    http://hdl.handle.net/10541/85590
    DOI
    10.1021/cc000075z
    PubMed ID
    11549359
    Type
    Article
    Language
    en
    ISSN
    1520-4766
    ae974a485f413a2113503eed53cd6c53
    10.1021/cc000075z
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Synthesis and anti-proliferative activity of fluoro-substituted chalcones.
    • Authors: Burmaoglu S, Algul O, Anıl DA, Gobek A, Duran GG, Ersan RH, Duran N
    • Issue date: 2016 Jul 1
    • Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones.
    • Authors: Mukherjee S, Kumar V, Prasad AK, Raj HG, Bracke ME, Olsen CE, Jain SC, Parmar VS
    • Issue date: 2001 Feb
    • Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.
    • Authors: Xia Y, Yang ZY, Xia P, Bastow KF, Nakanishi Y, Lee KH
    • Issue date: 2000 Apr 17
    • Efficient liquid-phase synthesis of 2'-hydroxychalcones.
    • Authors: Stoyanov EV, Champavier Y, Simon A, Basly JP
    • Issue date: 2002 Oct 7
    • Synthesis of different heterocycles-linked chalcone conjugates as cytotoxic agents and tubulin polymerization inhibitors.
    • Authors: Shankaraiah N, Nekkanti S, Brahma UR, Praveen Kumar N, Deshpande N, Prasanna D, Senwar KR, Jaya Lakshmi U
    • Issue date: 2017 Sep 1
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.