AffiliationCancer Research Campaign Gene Therapy Group, Paterson Institute for Cancer Research, Manchester, UK.
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AbstractGene therapy has thus far promised much and delivered little. Much of this has been due to deficiencies in the reagents and methodologies employed in early clinical trials. Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of gene transfer and expression in re-populating stem cells give cause for greater optimism. Here we review these advances and indicate areas requiring further development before clinical gene therapy in the haemopoietic system becomes a widely applicable treatment modality.
CitationProspects for gene therapy using haemopoietic stem cells. 2001, 14 (4):823-34 Best Pract Res Clin Haematol
JournalBest Practice & Research. Clinical Haematology
- [Development of gene therapy for hematopoietic stem cell using viral vectors].
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- Issue date: 2003 Apr
- Obstacles to human hematopoietic stem cell transduction by recombinant adeno-associated virus 2 vectors.
- Authors: Srivastava A
- Issue date: 2002
- Peripheral stem cells in bone marrow transplantation. Peripheral blood stem cell and gene therapy.
- Authors: Cavazzana-Calvo M, Bagnis C, Mannoni P, Fischer A
- Issue date: 1999 Mar-Jun
- Advances in lentiviral vector design for gene-modification of hematopoietic stem cells.
- Authors: Logan AC, Lutzko C, Kohn DB
- Issue date: 2002 Oct
- Genetic manipulation of hematopoietic stem cells.
- Authors: Larochelle A, Dunbar CE
- Issue date: 2004 Oct