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Tanning salon exposure and molecular alterations.

dc.contributor.authorWhitmore, S Elizabeth
dc.contributor.authorMorison, Warwick L
dc.contributor.authorPotten, Christopher S
dc.contributor.authorChadwick, Caroline A
dc.date.accessioned2009-11-06T10:49:56Z
dc.date.available2009-11-06T10:49:56Z
dc.date.issued2001-05
dc.identifier.citationTanning salon exposure and molecular alterations. 2001, 44 (5):775-80 J. Am. Acad. Dermatol.en
dc.identifier.issn0190-9622
dc.identifier.pmid11312423
dc.identifier.doi10.1067/mjd.2001.112581
dc.identifier.urihttp://hdl.handle.net/10541/85524
dc.description.abstractBACKGROUND: Human studies of the short-term cellular effects of tanning salon exposures are lacking. Findings of such studies may prove extremely helpful in educating consumers considering or currently attending tanning salons. OBJECTIVE: Our purpose was to determine whether tanning salon exposure causes DNA alterations and p53 protein expression in epidermal keratinocytes and/or circulating peripheral lymphocytes. METHODS: Eleven subjects received 10 full-body tanning salon exposures over a 2-week period. UV-induced DNA cyclobutane pyrimidine dimers and p53 protein expression were examined, comparing pretreatment peripheral blood lymphocytes and epidermal biopsy specimens with analogous specimens obtained after the 10 tanning salon exposures. RESULTS: Cyclobutane pyrimidine dimers in DNA and p53 protein expression were detected in epidermal keratinocytes, but were absent in lymphocytes. CONCLUSION: Similar to outdoor sun exposure, short-term recreational tanning salon exposure causes molecular alterations believed essential in the development of skin cancer.
dc.language.isoenen
dc.subjectTumour Suppressor Protein p53en
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshCommerce
dc.subject.meshDNA Damage
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshKeratinocytes
dc.subject.meshMale
dc.subject.meshPyrimidine Dimers
dc.subject.meshReference Values
dc.subject.meshTumor Suppressor Protein p53
dc.subject.meshUltraviolet Rays
dc.subject.meshUnited States
dc.titleTanning salon exposure and molecular alterations.en
dc.typeArticleen
dc.contributor.departmentDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.en
dc.identifier.journalJournal of the American Academy of Dermatologyen
html.description.abstractBACKGROUND: Human studies of the short-term cellular effects of tanning salon exposures are lacking. Findings of such studies may prove extremely helpful in educating consumers considering or currently attending tanning salons. OBJECTIVE: Our purpose was to determine whether tanning salon exposure causes DNA alterations and p53 protein expression in epidermal keratinocytes and/or circulating peripheral lymphocytes. METHODS: Eleven subjects received 10 full-body tanning salon exposures over a 2-week period. UV-induced DNA cyclobutane pyrimidine dimers and p53 protein expression were examined, comparing pretreatment peripheral blood lymphocytes and epidermal biopsy specimens with analogous specimens obtained after the 10 tanning salon exposures. RESULTS: Cyclobutane pyrimidine dimers in DNA and p53 protein expression were detected in epidermal keratinocytes, but were absent in lymphocytes. CONCLUSION: Similar to outdoor sun exposure, short-term recreational tanning salon exposure causes molecular alterations believed essential in the development of skin cancer.


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