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    Tanning salon exposure and molecular alterations.

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    Authors
    Whitmore, S Elizabeth
    Morison, Warwick L
    Potten, Christopher S
    Chadwick, Caroline A
    Affiliation
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
    Issue Date
    2001-05
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Human studies of the short-term cellular effects of tanning salon exposures are lacking. Findings of such studies may prove extremely helpful in educating consumers considering or currently attending tanning salons. OBJECTIVE: Our purpose was to determine whether tanning salon exposure causes DNA alterations and p53 protein expression in epidermal keratinocytes and/or circulating peripheral lymphocytes. METHODS: Eleven subjects received 10 full-body tanning salon exposures over a 2-week period. UV-induced DNA cyclobutane pyrimidine dimers and p53 protein expression were examined, comparing pretreatment peripheral blood lymphocytes and epidermal biopsy specimens with analogous specimens obtained after the 10 tanning salon exposures. RESULTS: Cyclobutane pyrimidine dimers in DNA and p53 protein expression were detected in epidermal keratinocytes, but were absent in lymphocytes. CONCLUSION: Similar to outdoor sun exposure, short-term recreational tanning salon exposure causes molecular alterations believed essential in the development of skin cancer.
    Citation
    Tanning salon exposure and molecular alterations. 2001, 44 (5):775-80 J. Am. Acad. Dermatol.
    Journal
    Journal of the American Academy of Dermatology
    URI
    http://hdl.handle.net/10541/85524
    DOI
    10.1067/mjd.2001.112581
    PubMed ID
    11312423
    Type
    Article
    Language
    en
    ISSN
    0190-9622
    ae974a485f413a2113503eed53cd6c53
    10.1067/mjd.2001.112581
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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