Affiliation
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.Issue Date
2001-05
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Show full item recordAbstract
BACKGROUND: Human studies of the short-term cellular effects of tanning salon exposures are lacking. Findings of such studies may prove extremely helpful in educating consumers considering or currently attending tanning salons. OBJECTIVE: Our purpose was to determine whether tanning salon exposure causes DNA alterations and p53 protein expression in epidermal keratinocytes and/or circulating peripheral lymphocytes. METHODS: Eleven subjects received 10 full-body tanning salon exposures over a 2-week period. UV-induced DNA cyclobutane pyrimidine dimers and p53 protein expression were examined, comparing pretreatment peripheral blood lymphocytes and epidermal biopsy specimens with analogous specimens obtained after the 10 tanning salon exposures. RESULTS: Cyclobutane pyrimidine dimers in DNA and p53 protein expression were detected in epidermal keratinocytes, but were absent in lymphocytes. CONCLUSION: Similar to outdoor sun exposure, short-term recreational tanning salon exposure causes molecular alterations believed essential in the development of skin cancer.Citation
Tanning salon exposure and molecular alterations. 2001, 44 (5):775-80 J. Am. Acad. Dermatol.Journal
Journal of the American Academy of DermatologyDOI
10.1067/mjd.2001.112581PubMed ID
11312423Type
ArticleLanguage
enISSN
0190-9622ae974a485f413a2113503eed53cd6c53
10.1067/mjd.2001.112581
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