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dc.contributor.authorMerry, Catherine L R
dc.contributor.authorWilson, Valerie A
dc.date.accessioned2009-11-06T09:15:26Z
dc.date.available2009-11-06T09:15:26Z
dc.date.issued2002-12-19
dc.identifier.citationRole of heparan sulfate-2-O-sulfotransferase in the mouse. 2002, 1573 (3):319-27 Biochim. Biophys. Actaen
dc.identifier.issn0006-3002
dc.identifier.pmid12417414
dc.identifier.urihttp://hdl.handle.net/10541/85497
dc.description.abstractHeparan sulfate (HS) is a long unbranched polysaccharide found covalently attached to various proteins at the cell surface and in the extracellular matrix. It plays a central role in embryonic development and cellular function by modulating the activities of an extensive range of growth factors and morphogens. HS 2-O-sulfotransferase (Hs2st) occupies a critical position in the succession of enzymes responsible for the biosynthesis of HS, catalysing the transfer of sulfate to the C2-position of selected hexuronic acid residues within the nascent HS chain. Previous studies have concluded that 2-O-sulfation of HS is essential for it to cooperate in many growth factor/receptor interactions. Surprisingly therefore, embryos lacking functional Hs2st survive until birth, but die perinatally, suffering complete failure to form kidneys. However, this rather late lethality belies a more intricate involvement of 2-O-sulfated HS during development. The purpose of this review is to summarise the requirements for 2-O-sulfated HS during mouse development, at the morphological and molecular level. The implications that altered HS structure may have on growth factor/receptor signalling in vivo will be discussed.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshGrowth Substances
dc.subject.meshHeparitin Sulfate
dc.subject.meshMice
dc.subject.meshPhenotype
dc.subject.meshReceptors, Growth Factor
dc.subject.meshSignal Transduction
dc.subject.meshSulfotransferases
dc.titleRole of heparan sulfate-2-O-sulfotransferase in the mouse.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign, Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom.en
dc.identifier.journalBiochimica et Biophysica Actaen
html.description.abstractHeparan sulfate (HS) is a long unbranched polysaccharide found covalently attached to various proteins at the cell surface and in the extracellular matrix. It plays a central role in embryonic development and cellular function by modulating the activities of an extensive range of growth factors and morphogens. HS 2-O-sulfotransferase (Hs2st) occupies a critical position in the succession of enzymes responsible for the biosynthesis of HS, catalysing the transfer of sulfate to the C2-position of selected hexuronic acid residues within the nascent HS chain. Previous studies have concluded that 2-O-sulfation of HS is essential for it to cooperate in many growth factor/receptor interactions. Surprisingly therefore, embryos lacking functional Hs2st survive until birth, but die perinatally, suffering complete failure to form kidneys. However, this rather late lethality belies a more intricate involvement of 2-O-sulfated HS during development. The purpose of this review is to summarise the requirements for 2-O-sulfated HS during mouse development, at the morphological and molecular level. The implications that altered HS structure may have on growth factor/receptor signalling in vivo will be discussed.


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