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dc.contributor.authorMerry, Catherine L R
dc.contributor.authorGallagher, John T
dc.date.accessioned2009-11-06T09:14:36Z
dc.date.available2009-11-06T09:14:36Z
dc.date.issued2002
dc.identifier.citationNew insights into heparan sulphate biosynthesis from the study of mutant mice. 2002 (69):47-57 Biochem. Soc. Symp.en
dc.identifier.issn0067-8694
dc.identifier.pmid12655773
dc.identifier.urihttp://hdl.handle.net/10541/85496
dc.description.abstractHeparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS-ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st -/- mice.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCarbohydrate Sequence
dc.subject.meshHeparitin Sulfate
dc.subject.meshMice
dc.subject.meshMice, Mutant Strains
dc.subject.meshMolecular Sequence Data
dc.titleNew insights into heparan sulphate biosynthesis from the study of mutant mice.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Department of Medical Oncology, Christie Research Centre, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, U.K. cmerry@picr.man.ac.uken
dc.identifier.journalBiochemical Society Symposiumen
html.description.abstractHeparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS-ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st -/- mice.


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