New insights into heparan sulphate biosynthesis from the study of mutant mice.
AffiliationCancer Research UK Department of Medical Oncology, Christie Research Centre, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, U.K. firstname.lastname@example.org
MetadataShow full item record
AbstractHeparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS-ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st -/- mice.
CitationNew insights into heparan sulphate biosynthesis from the study of mutant mice. 2002 (69):47-57 Biochem. Soc. Symp.
JournalBiochemical Society Symposium
- The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse.
- Authors: Merry CL, Bullock SL, Swan DC, Backen AC, Lyon M, Beddington RS, Wilson VA, Gallagher JT
- Issue date: 2001 Sep 21
- Molecular analysis of heparan sulfate biosynthetic enzyme machinery and characterization of heparan sulfate structure in Nematostella vectensis.
- Authors: Feta A, Do AT, Rentzsch F, Technau U, Kusche-Gullberg M
- Issue date: 2009 May 1
- Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
- Authors: Wilson VA, Gallagher JT, Merry CL
- Issue date: 2002 May-Jun
- Heparan sulphate in the binding and activation of basic fibroblast growth factor.
- Authors: Gallagher JT, Turnbull JE
- Issue date: 1992 Dec
- Heparan Sulfate: Biosynthesis, Structure, and Function.
- Authors: Li JP, Kusche-Gullberg M
- Issue date: 2016