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    The Scottish and Manchester randomised trial of neo-adjuvant chemotherapy for advanced cervical cancer.

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    Authors
    Symonds, R P
    Habeshaw, T
    Reed, N S
    Paul, J
    Pyper, E
    Yosef, H
    Davis, J
    Hunter, Robin D
    Davidson, Susan E
    Stewart, Alan L
    Cowie, V
    Sarkar, T
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    Affiliation
    Beatson Oncology Centre, Western Infirmary, Glasgow, UK. psymonds@uhl.trent.nhs.uk
    Issue Date
    2000-05
    
    Metadata
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    Abstract
    204 eligible patients were entered into a multicentre randomised trial of neo-adjuvant chemotherapy prior to radical radiotherapy. The aim of this study was to assess whether there was any survival advantage in patients undergoing chemotherapy and radiotherapy compared with those given radiotherapy alone. Patients were aged up to 70 years, performance status 0-1/2, with bulky stage IIb, stage III or stage IVa squamous or adenosquamous carcinoma. Three cycles of methotrexate 100 mg/m2 and cisplatin 50 mg/m2 were given at 2-weekly intervals before radical radiotherapy. 104 eligible patients received the combination treatment and 100 radiotherapy only. The two arms of the study were well balanced for tumour and patient characteristics. The response rate to chemotherapy was 49%, 33% of patients in the radiotherapy (XRT) alone arm and 45% of the combination arm were clinically free of tumour at the end of treatment. The median follow-up for surviving patients is 5.4 years (range: 11 months-8 years) and 84% have been followed-up for more than 4 years. 134 patients have died (68 XRT only, 66 combined arm). The median survival RT alone was 111 weeks (95% confidence interval (CI) 72-151 weeks), combination arm 125 weeks (95% CI 79-170 weeks). The estimated death ratio is 0.79 (P = 0.19, 95% CI 0.56-1.12). The estimated 3-year survival is 40% (95% CI 30-50%) RT only compared with 47% (95% CI 37-57%) in the combination arm. Acute and late toxicity of radiotherapy was not increased by the addition of chemotherapy.
    Citation
    The Scottish and Manchester randomised trial of neo-adjuvant chemotherapy for advanced cervical cancer. 2000, 36 (8):994-1001 Eur. J. Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/85473
    DOI
    10.1016/S0959-8049(00)00034-4
    PubMed ID
    10885603
    Type
    Article
    Language
    en
    ISSN
    0959-8049
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0959-8049(00)00034-4
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