The UK national breast cancer screening programme for survivors of Hodgkin lymphoma detects breast cancer at an early stage.
AuthorsHowell, Sacha J
Linton, Kim M
Cowan, Richard A
Harris, Maggie A
Wardley, Andrew M
Radford, John A
AffiliationDepartment of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK. Showell@picr.man.ac.uk
MetadataShow full item record
AbstractBACKGROUND: Supradiaphragmatic radiotherapy (SRT) to treat Hodgkin's lymphoma (HL) at a young age increases the risk of breast cancer (BC). A national notification risk assessment and screening programme (NRASP) for women who were treated with SRT before the age of 36 years was instituted in the United Kingdom in 2003. In this study, we report the implementation and screening results from the largest English Cancer Network. METHODS: A total of 417 eligible women were identified through cancer registry/hospital databases and from follow-up (FU) clinics. Screening results were collated retrospectively, and registry searches were used to capture BC cases. RESULTS: Of the 417 women invited for clinical review, 243 (58%) attended. Of these 417 women, 23 (5.5%) have been diagnosed with BC, a standardised incidence ratio of 2.9 compared with the age-matched general population. Of five invasive BCs diagnosed within the NRASP, none involved axillary lymph nodes compared with 7 of 13 (54%) diagnosed outside the programme (P<0.10). The mean latency for BC cases was 19.5+/-8.35 years and the mean FU duration for those unaffected by BC was 14.6+/-9.11 years (P<0.01), suggesting that those unaffected by BC remain at high risk. Recall and negative biopsy rates were acceptable (10.5 and 0.8%, respectively). CONCLUSIONS: The NRASP appears to detect BC at an early stage with acceptable biopsy rates, although numbers are small. Determination of NRASP results on a national basis is required for the accurate evaluation of screening efficacy in women previously treated with SRT.
CitationThe UK national breast cancer screening programme for survivors of Hodgkin lymphoma detects breast cancer at an early stage. 2009, 101 (4):582-8 Br. J. Cancer
JournalBritish Journal of Cancer
- Screening mammography for young women treated with supradiaphragmatic radiation for Hodgkin's lymphoma.
- Authors: Lee L, Pintilie M, Hodgson DC, Goss PE, Crump M
- Issue date: 2008 Jan
- Breast Imaging in Women Previously Irradiated for Hodgkin Lymphoma.
- Authors: Horst KC, Fero KE, Hancock SL, Advani RH, Ikeda DM, Daniel B, Rosenberg SA, Donaldson SS, Hoppe RT
- Issue date: 2016 Apr
- Risk of breast cancer and breast cancer characteristics in women treated with supradiaphragmatic radiation for Hodgkin lymphoma: Mayo Clinic experience.
- Authors: Wahner-Roedler DL, Nelson DF, Croghan IT, Achenbach SJ, Crowson CS, Hartmann LC, O'Fallon WM
- Issue date: 2003 Jun
- Breast cancer risk in female survivors of Hodgkin's lymphoma: lower risk after smaller radiation volumes.
- Authors: De Bruin ML, Sparidans J, van't Veer MB, Noordijk EM, Louwman MW, Zijlstra JM, van den Berg H, Russell NS, Broeks A, Baaijens MH, Aleman BM, van Leeuwen FE
- Issue date: 2009 Sep 10
- Impact of Early Breast Cancer Screening on Mortality Among Young Survivors of Childhood Hodgkin's Lymphoma.
- Authors: Hodgson DC, Cotton C, Crystal P, Nathan PC
- Issue date: 2016 Jul
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