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dc.contributor.authorShervington, Leroy A
dc.contributor.authorSmith, Nigel K
dc.contributor.authorNorman, Emma
dc.contributor.authorWard, Timothy H
dc.contributor.authorPhillips, Roger M
dc.contributor.authorShervington, Amal
dc.date.accessioned2009-11-03T12:47:09Z
dc.date.available2009-11-03T12:47:09Z
dc.date.issued2009-07
dc.identifier.citationTo determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines. 2009, 44 (7):2944-51 Eur J Med Chemen
dc.identifier.issn1768-3254
dc.identifier.pmid19121874
dc.identifier.doi10.1016/j.ejmech.2008.11.014
dc.identifier.urihttp://hdl.handle.net/10541/85220
dc.description.abstractFour ester prodrugs derived from the bifunctional alkylating agent chlorambucil, and one of its nitro-derivatives, 3-nitrochlorambucil conjugated to prasterone and pregnenolone, were synthesized and tested for their cytotoxic activity against eight human cell lines, using the standard MTT assay. A comparison between the esters and the controls, namely chlorambucil and 3-nitrochlorambucil would suggest that all four esters possess to varying degrees, specificity towards the breast adenocarcinoma cell line (MDA-mb468) than the other seven cells' lines tested. The overall findings are encouraging since it infers that these lipophilic esters not only have the ability to traverse specific cell membranes but also exhibit cytotoxicity towards most of the cell lines tested.
dc.language.isoenen
dc.subjectCell Line Tumouren
dc.subjectCanceren
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents
dc.subject.meshCell Line, Tumor
dc.subject.meshChlorambucil
dc.subject.meshChromatography, High Pressure Liquid
dc.subject.meshDehydroepiandrosterone
dc.subject.meshEsters
dc.subject.meshHumans
dc.subject.meshInhibitory Concentration 50
dc.subject.meshNeoplasms
dc.subject.meshNitro Compounds
dc.subject.meshPregnenolone
dc.titleTo determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines.en
dc.typeArticleen
dc.contributor.departmentSchool of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire, Preston, UK. lashervington@uclan.ac.uken
dc.identifier.journalEuropean Journal of Medicinal Chemistryen
html.description.abstractFour ester prodrugs derived from the bifunctional alkylating agent chlorambucil, and one of its nitro-derivatives, 3-nitrochlorambucil conjugated to prasterone and pregnenolone, were synthesized and tested for their cytotoxic activity against eight human cell lines, using the standard MTT assay. A comparison between the esters and the controls, namely chlorambucil and 3-nitrochlorambucil would suggest that all four esters possess to varying degrees, specificity towards the breast adenocarcinoma cell line (MDA-mb468) than the other seven cells' lines tested. The overall findings are encouraging since it infers that these lipophilic esters not only have the ability to traverse specific cell membranes but also exhibit cytotoxicity towards most of the cell lines tested.


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