To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines.
Authors
Shervington, Leroy ASmith, Nigel K
Norman, Emma
Ward, Timothy H
Phillips, Roger M
Shervington, Amal
Affiliation
School of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire, Preston, UK. lashervington@uclan.ac.ukIssue Date
2009-07
Metadata
Show full item recordAbstract
Four ester prodrugs derived from the bifunctional alkylating agent chlorambucil, and one of its nitro-derivatives, 3-nitrochlorambucil conjugated to prasterone and pregnenolone, were synthesized and tested for their cytotoxic activity against eight human cell lines, using the standard MTT assay. A comparison between the esters and the controls, namely chlorambucil and 3-nitrochlorambucil would suggest that all four esters possess to varying degrees, specificity towards the breast adenocarcinoma cell line (MDA-mb468) than the other seven cells' lines tested. The overall findings are encouraging since it infers that these lipophilic esters not only have the ability to traverse specific cell membranes but also exhibit cytotoxicity towards most of the cell lines tested.Citation
To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines. 2009, 44 (7):2944-51 Eur J Med ChemJournal
European Journal of Medicinal ChemistryDOI
10.1016/j.ejmech.2008.11.014PubMed ID
19121874Type
ArticleLanguage
enISSN
1768-3254ae974a485f413a2113503eed53cd6c53
10.1016/j.ejmech.2008.11.014
Scopus Count
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