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    Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk.

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    Authors
    Barrett-Lee, P J
    Dixon, J M
    Farrell, Carole
    Jones, A
    Leonard, R
    Murray, N
    Palmieri, C
    Plummer, C J
    Stanley, A
    Verrill, Mark W
    Affiliation
    Breast Unit, Velindre Cancer Centre, Cardiff, UK. peter.barrett-lee@velindre-tr.wales.nhs.uk
    Issue Date
    2009-05
    
    Metadata
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    Abstract
    Anthracyclines are considered to be among the most active agents for the treatment of breast cancer. However, their use is limited by cumulative, dose-related cardiotoxicity. Such cardiotoxicity results in a permanent loss of cardiac myocytes and a progressive reduction in cardiac function following each subsequent dose of anthracycline. Initially, damage to the heart is subclinical; however, increasingly impaired cardiac function can result in cardiovascular symptoms, with serious cardiac injury resulting in chronic heart failure. Since the early detection and treatment of cardiotoxicity can reduce its clinical effects, it is important that oncologists are aware of these adverse effects and manage them appropriately. This review examines the risk factors for anthracycline-associated cardiotoxicity and offers recommendations on strategies to reduce the cardiotoxicity of anthracyclines in the management of patients with advanced breast cancer.
    Citation
    Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk. 2009, 20 (5):816-27 Ann. Oncol.
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/85170
    DOI
    10.1093/annonc/mdn728
    PubMed ID
    19153118
    Type
    Article
    Language
    en
    ISSN
    1569-8041
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdn728
    Scopus Count
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