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    Chromosomal radiosensitivity and low penetrance predisposition to cancer.

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    Authors
    Scott, David
    Affiliation
    Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK. david.scott2004@btinternet.com
    Issue Date
    2004
    
    Metadata
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    Abstract
    This mini-review summarises studies in this Institute on the sensitivity of cells of patients with common cancers to the chromosome-damaging effects of ionising radiation, in the context of related studies. Using the 90th percentile of healthy controls (n >200) as the cut-off point between a normal and a sensitive response, 40% of patients with breast cancer (n = 166) were sensitive when cells were irradiated in the G2 phase of the cell cycle. Smaller studies showed that patients with colorectal, head and neck (at < 45 years) and childhood cancers also exhibited degrees of enhanced sensitivity, whereas cervical and lung cancer cases did not. Cells from breast and head and neck cases irradiated in G(0) also showed increased sensitivity. We propose that such elevated sensitivity is a marker of low penetrance predisposition to cancer. The strongest support for this hypothesis was our demonstration of the Mendelian heritability of chromosomal radiosensitivity in 95 family members of breast cancer cases. Challenges for the future include more heritability studies, identification of the underlying genetic determinants, assessment of the associated cancer risk (spontaneous and radiogenic) and population screening for cancer prevention strategies.
    Citation
    Chromosomal radiosensitivity and low penetrance predisposition to cancer. 2004, 104 (1-4):365-70 Cytogenet. Genome Res.
    Journal
    Cytogenetic and Genome Research
    URI
    http://hdl.handle.net/10541/84454
    DOI
    10.1159/000077517
    PubMed ID
    15162066
    Language
    en
    ISSN
    1424-859X
    ae974a485f413a2113503eed53cd6c53
    10.1159/000077517
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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    Related articles

    • Chromosomal radiosensitivity as a marker of predisposition to common cancers?
    • Authors: Baria K, Warren C, Roberts SA, West CM, Scott D
    • Issue date: 2001 Apr 6
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    • Issue date: 2002 May
    • Chromosomal mutagen sensitivity associated with mutations in BRCA genes.
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    • Chromosomal radiosensitivity, cancer predisposition and response to radiotherapy.
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    • Elevated G2 chromosomal radiosensitivity in Irish breast cancer patients: a comparison with other studies.
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