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Oncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer.

dc.contributor.authorNaganuma, Hiroshi
dc.contributor.authorKono, Koji
dc.contributor.authorMori, Yoshiyuki
dc.contributor.authorTakayoshi, Sekikawa
dc.contributor.authorStern, Peter L
dc.contributor.authorTasaka, Kachio
dc.contributor.authorMatsumoto, Yoshiro
dc.date.accessioned2009-10-16T11:07:34Z
dc.date.available2009-10-16T11:07:34Z
dc.date.issued2009-10-16T11:07:34Z
dc.identifier.citationOncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer., 22 (2B):1033-8 Anticancer Res.en
dc.identifier.issn0250-7005
dc.identifier.pmid12168897
dc.identifier.urihttp://hdl.handle.net/10541/84335
dc.description.abstractBACKGROUND: Oncofetal antigen 5T4 is defined by a monoclonal antibody raised against placental trophoblast membranes. Antigen 5T4 is reported to be expressed only on trophoblasts and neoplastic cells and would be a potentially useful marker for neoplastic cells. MATERIALS AND METHODS: We evaluated the expression of 5T4 oncofetal antigen in gastric cancer by immunohistochemistry and investigated whether or not the expression of this antigen is correlated with the prognosis of patients with gastric cancer. RESULTS: The 5T4 antigen was detected in 51.6% of primary gastric cancer (n = 62) and 5T4-reactivity was more frequently observed in carcinoma with lymph node metastasis (p < 0.05). The overall survival of 5T4-positive patients was significantly worse than that of 5T4-negative patients, analyzed by the log-rank test (p < 0.05), although multivariate analysis indicated that 5T4 expression was not an independent prognostic factor. CONCLUSION: The assessment of 5T4 expression may be useful in identifying gastric cancer patients with a poor prognosis.
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectStomach Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAged
dc.subject.meshAntigens, Neoplasm
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMembrane Glycoproteins
dc.subject.meshMiddle Aged
dc.subject.meshPrognosis
dc.subject.meshStomach Neoplasms
dc.subject.meshTumor Markers, Biological
dc.titleOncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer.en
dc.typeArticleen
dc.identifier.journalAnticancer Researchen
html.description.abstractBACKGROUND: Oncofetal antigen 5T4 is defined by a monoclonal antibody raised against placental trophoblast membranes. Antigen 5T4 is reported to be expressed only on trophoblasts and neoplastic cells and would be a potentially useful marker for neoplastic cells. MATERIALS AND METHODS: We evaluated the expression of 5T4 oncofetal antigen in gastric cancer by immunohistochemistry and investigated whether or not the expression of this antigen is correlated with the prognosis of patients with gastric cancer. RESULTS: The 5T4 antigen was detected in 51.6% of primary gastric cancer (n = 62) and 5T4-reactivity was more frequently observed in carcinoma with lymph node metastasis (p < 0.05). The overall survival of 5T4-positive patients was significantly worse than that of 5T4-negative patients, analyzed by the log-rank test (p < 0.05), although multivariate analysis indicated that 5T4 expression was not an independent prognostic factor. CONCLUSION: The assessment of 5T4 expression may be useful in identifying gastric cancer patients with a poor prognosis.


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