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    Oncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer.

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    Authors
    Naganuma, Hiroshi
    Kono, Koji
    Mori, Yoshiyuki
    Takayoshi, Sekikawa
    Stern, Peter L
    Tasaka, Kachio
    Matsumoto, Yoshiro
    Issue Date
    2009-10-16T11:07:34Z
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Oncofetal antigen 5T4 is defined by a monoclonal antibody raised against placental trophoblast membranes. Antigen 5T4 is reported to be expressed only on trophoblasts and neoplastic cells and would be a potentially useful marker for neoplastic cells. MATERIALS AND METHODS: We evaluated the expression of 5T4 oncofetal antigen in gastric cancer by immunohistochemistry and investigated whether or not the expression of this antigen is correlated with the prognosis of patients with gastric cancer. RESULTS: The 5T4 antigen was detected in 51.6% of primary gastric cancer (n = 62) and 5T4-reactivity was more frequently observed in carcinoma with lymph node metastasis (p < 0.05). The overall survival of 5T4-positive patients was significantly worse than that of 5T4-negative patients, analyzed by the log-rank test (p < 0.05), although multivariate analysis indicated that 5T4 expression was not an independent prognostic factor. CONCLUSION: The assessment of 5T4 expression may be useful in identifying gastric cancer patients with a poor prognosis.
    Citation
    Oncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer., 22 (2B):1033-8 Anticancer Res.
    Journal
    Anticancer Research
    URI
    http://hdl.handle.net/10541/84335
    PubMed ID
    12168897
    Type
    Article
    Language
    en
    ISSN
    0250-7005
    Collections
    All Paterson Institute for Cancer Research

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